trans-4-(4-indazol-1-ylpyrimidin-2-ylamino)-cyclohexanecarboxylic acid ethyl ester

Base Information

Chemical Name:trans-4-(4-indazol-1-ylpyrimidin-2-ylamino)-cyclohexanecarboxylic acid ethyl ester
CAS No.:1032452-69-9
Molecular Formula:C₂₀H₂₃N₅O₂
Molecular Weight:365.435
Hs Code.:

Synonyms:trans-4-(4-indazol-1-ylpyrimidin-2-ylamino)-cyclohexanecarboxylic acid ethyl ester

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Chemical Property of trans-4-(4-indazol-1-ylpyrimidin-2-ylamino)-cyclohexanecarboxylic acid ethyl ester

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Technology Process of trans-4-(4-indazol-1-ylpyrimidin-2-ylamino)-cyclohexanecarboxylic acid ethyl ester

There total 3 articles about trans-4-(4-indazol-1-ylpyrimidin-2-ylamino)-cyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1032452-66-6
1-(2-methanesulfonyl-pyrimidin-4-yl)-1H-indazole

: 1678-68-8
ethyl trans-4-aminocyclohexanecarboxylate

: 1032452-69-9
trans-4-(4-indazol-1-ylpyrimidin-2-ylamino)-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 60 ℃;

Reference yield:

: 271-44-3
benzimidazole

: 1032452-69-9
trans-4-(4-indazol-1-ylpyrimidin-2-ylamino)-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 2.5 h / 20 - 70 °C

2.1: 3-chloro-benzenecarboperoxoic acid / chloroform / Cooling with acetone-dry ice

3.1: triethylamine / tetrahydrofuran / 60 °C

With sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 1032451-38-9
1-(2-methylsulfanyl-pyrimidin-4-yl)-1H-indazole

: 1032452-69-9
trans-4-(4-indazol-1-ylpyrimidin-2-ylamino)-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / chloroform / Cooling with acetone-dry ice

2: triethylamine / tetrahydrofuran / 60 °C

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; chloroform;