Technology Process of 2,6-dibromo-3-nitro-4-chloropyridine
There total 6 articles about 2,6-dibromo-3-nitro-4-chloropyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride; sodium nitrite;
In
water;
at 0 ℃;
for 1h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: urea hydrogen peroxide adduct; trifluoroacetic anhydride / dichloromethane / 20.75 h / 5 - 20 °C / Inert atmosphere
2: sulfuric acid; nitric acid / 3.92 h / 79 - 85 °C
3: iron; acetic acid / 0.75 h
4: sulfuric acid; nitric acid / 0.5 h / -10 - -5 °C
5: sulfuric acid / 1.58 h / 47 - 56 °C
6: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C
With
hydrogenchloride; sulfuric acid; nitric acid; urea hydrogen peroxide adduct; iron; acetic acid; trifluoroacetic anhydride; sodium nitrite;
In
dichloromethane; water;
DOI:10.1016/j.tetlet.2011.08.119
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sulfuric acid; nitric acid / 0.5 h / -10 - -5 °C
2: sulfuric acid / 1.58 h / 47 - 56 °C
3: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C
With
hydrogenchloride; sulfuric acid; nitric acid; sodium nitrite;
In
water;
DOI:10.1016/j.tetlet.2011.08.119
