2,2-dimethyl-propionic acid 5-(4-methoxy-benzyloxy)-8-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-6-oxo-octa-2,7-dienyl ester

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Chemical Name:2,2-dimethyl-propionic acid 5-(4-methoxy-benzyloxy)-8-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-6-oxo-octa-2,7-dienyl ester
CAS No.:676474-14-9
Molecular Formula:C₂₇H₃₆O₆
Molecular Weight:456.579
Hs Code.:

Synonyms:2,2-dimethyl-propionic acid 5-(4-methoxy-benzyloxy)-8-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-6-oxo-octa-2,7-dienyl ester

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Chemical Property of 2,2-dimethyl-propionic acid 5-(4-methoxy-benzyloxy)-8-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-6-oxo-octa-2,7-dienyl ester

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Technology Process of 2,2-dimethyl-propionic acid 5-(4-methoxy-benzyloxy)-8-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-6-oxo-octa-2,7-dienyl ester

There total 8 articles about 2,2-dimethyl-propionic acid 5-(4-methoxy-benzyloxy)-8-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-6-oxo-octa-2,7-dienyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 218898-32-9
(2S)-4-methyl-3,6-dihydro-2H-pyran-2-carbaldehyde

: 676473-75-9
2,2-dimethyl-propionic acid 7-(dimethoxy-phosphoryl)-5-(4-methoxy-benzyloxy)-6-oxo-hept-2-enyl ester

: 676474-14-9
2,2-dimethyl-propionic acid 5-(4-methoxy-benzyloxy)-8-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-6-oxo-octa-2,7-dienyl ester

Guidance literature:: With triethylamine; lithium chloride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2003.12.001

Reference yield:

: 3282-30-2
pivaloyl chloride

: 676474-14-9
2,2-dimethyl-propionic acid 5-(4-methoxy-benzyloxy)-8-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-6-oxo-octa-2,7-dienyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂

2: 70 percent / Et₃N; LiCl / tetrahydrofuran / 0 - 20 °C

With pyridine; triethylamine; lithium chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2003.12.001

Reference yield:

: 152453-72-0
2-deoxy-3-O-<(4-methoxyphenyl)methyl>-4,5-O-(1-methylethylidene)-D-erythro-pentose

: 676474-14-9
2,2-dimethyl-propionic acid 5-(4-methoxy-benzyloxy)-8-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-6-oxo-octa-2,7-dienyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: NaH / tetrahydrofuran / 0 °C

1.2: 85 percent / Bu₃P / acetonitrile / 60 °C

2.1: DIBAL / CH₂Cl₂ / -78 °C

3.1: 85 percent / pyridine / CH₂Cl₂

4.1: aq. HCl / tetrahydrofuran

5.1: NaIO₄ / tetrahydrofuran; H₂O / 0 °C

6.1: NaClO₂; H₂NSO₃H / 2-methyl-propan-2-ol; H₂O / 0 °C

7.1: 50 percent / methanol; toluene

8.1: tetrahydrofuran / -78 °C

9.1: pyridine / CH₂Cl₂

10.1: 70 percent / Et₃N; LiCl / tetrahydrofuran / 0 - 20 °C

With pyridine; hydrogenchloride; sodium chlorite; sodium periodate; aminosulfonic acid; sodium hydride; diisobutylaluminium hydride; triethylamine; lithium chloride; In tetrahydrofuran; methanol; dichloromethane; water; toluene; tert-butyl alcohol; 1.1: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/j.bmcl.2003.12.001