dimethyl 1,2,3,4-tetrahydro-2-(4-methoxycyclohexa-1,5-dienyl)isoquinolin-1-ylphosphonate

Base Information

Chemical Name:dimethyl 1,2,3,4-tetrahydro-2-(4-methoxycyclohexa-1,5-dienyl)isoquinolin-1-ylphosphonate
CAS No.:1184912-65-9
Molecular Formula:C₁₈H₂₂NO₄P
Molecular Weight:347.351
Hs Code.:

Synonyms:dimethyl 1,2,3,4-tetrahydro-2-(4-methoxycyclohexa-1,5-dienyl)isoquinolin-1-ylphosphonate

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Chemical Property of dimethyl 1,2,3,4-tetrahydro-2-(4-methoxycyclohexa-1,5-dienyl)isoquinolin-1-ylphosphonate

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Technology Process of dimethyl 1,2,3,4-tetrahydro-2-(4-methoxycyclohexa-1,5-dienyl)isoquinolin-1-ylphosphonate

There total 5 articles about dimethyl 1,2,3,4-tetrahydro-2-(4-methoxycyclohexa-1,5-dienyl)isoquinolin-1-ylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 78317-83-6
2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

: 868-85-9
Dimethyl phosphite

: 1184912-65-9
dimethyl 1,2,3,4-tetrahydro-2-(4-methoxycyclohexa-1,5-dienyl)isoquinolin-1-ylphosphonate

Guidance literature:: With oxygen; molybdenum(VI) oxide; In methanol; at 60 ℃; for 24h; under 760.051 Torr;
DOI:10.1016/j.tetlet.2012.01.031

Reference yield:

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 1184912-65-9
dimethyl 1,2,3,4-tetrahydro-2-(4-methoxycyclohexa-1,5-dienyl)isoquinolin-1-ylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; potassium phosphate / ethylene glycol; isopropyl alcohol / 24 h / 90 °C / Inert atmosphere

2: oxygen; molybdenum(VI) oxide / methanol / 24 h / 60 °C / 760.05 Torr

With potassium phosphate; copper(l) iodide; oxygen; molybdenum(VI) oxide; In methanol; ethylene glycol; isopropyl alcohol;
DOI:10.1016/j.tetlet.2012.01.031

Reference yield:

: 100-52-7
benzaldehyde

: 1184912-65-9
dimethyl 1,2,3,4-tetrahydro-2-(4-methoxycyclohexa-1,5-dienyl)isoquinolin-1-ylphosphonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium acetate; acetic acid / 1.5 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / Reflux

3.1: formic acid / 0.17 h / 0 °C

3.2: 24 h / 50 °C

4.1: copper(l) iodide; potassium phosphate / ethylene glycol; isopropyl alcohol / 24 h / 90 °C / Inert atmosphere

5.1: oxygen; molybdenum(VI) oxide / methanol / 24 h / 60 °C / 760.05 Torr

With potassium phosphate; copper(l) iodide; lithium aluminium tetrahydride; formic acid; ammonium acetate; oxygen; acetic acid; molybdenum(VI) oxide; In tetrahydrofuran; methanol; ethylene glycol; isopropyl alcohol;
DOI:10.1016/j.tetlet.2012.01.031