3-BROMO-4-METHYL-5-NITROBENZOIC ACID METHYL ESTER

Base Information

• Chemical Name: 3-BROMO-4-METHYL-5-NITROBENZOIC ACID METHYL ESTER
• CAS No.: 223519-08-2
• Molecular Formula: C9H8 Br N O4
• Molecular Weight: 274.071
• Hs Code.: 2916399090
• Mol file: 223519-08-2.mol

Synonyms:3-BROMO-4-METHYL-5-NITROBENZOIC ACID METHYL ESTER;3-BROMO-4-MEHTYL-5-NITROBENZOIC ACID METHYL ESTER

Chemical Property of 3-BROMO-4-METHYL-5-NITROBENZOIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.000103mmHg at 25°C
• Refractive Index: 1.579
• Boiling Point: 337.7°Cat760mmHg
• Flash Point: 158°C
• PSA: 72.12000
• Density: 1.596g/cm³
• LogP: 2.97550
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl3-bromo-4-methyl-5-nitrobenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-4-METHYL-5-NITROBENZOIC ACID METHYL ESTER

There total 3 articles about 3-BROMO-4-METHYL-5-NITROBENZOIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methanol (67-56-1) + 3-bromo-4-methyl-5-nitro-benzoic acid (34545-20-5) → methyl 3-bromo-4-methyl-5-nitrobenzoate (223519-08-2)

Guidance literature:

With sulfuric acid; for 8h; Reflux;

Reference yield:

methyl 4-bromo-1H-indole-6-carboxylate (882679-96-1) → methyl 3-bromo-4-methyl-5-nitrobenzoate (223519-08-2)

Guidance literature:

methyl 4-bromo-1H-indole-6-carboxylate; With N,N-dimethyl-formamide dimethyl acetal; In N,N-dimethyl-formamide; at 120 ℃; for 6h;

With iron; acetic acid; In N,N-dimethyl-formamide; at 100 ℃;

Reference yield:

4-methyl-3-nitrobenzoic acid (96-98-0) → methyl 3-bromo-4-methyl-5-nitrobenzoate (223519-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1: DBDMH / sulfuric acid / 16 h / 20 °C

2: thionyl chloride / -5 °C / Reflux

With thionyl chloride; In sulfuric acid;

upstream raw materials:

4-methyl-3-nitrobenzoic acid

methanol

3-bromo-4-methyl-5-nitro-benzoic acid

methyl 4-bromo-1H-indole-6-carboxylate

Downstream raw materials:

C₂₁H₂₅N₅O

1-(4-(6-(N-(2-(piperidin-1-yl)ethyl)aminocarbonyl)-1H-indazol-4-yl)phenyl)-3-(3-(trifluoromethoxy)phenyl)urea

methyl 4-bromo-1H-indazole-6-carboxylate

4-bromo-1H-indazole-6-carboxylic acid