ethyl (3R,4R,5S)-4-acetylamino-5-tert-butoxycarbonylamino-3-hydroxy-cyclohex-1-enecarboxylate

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Chemical Name:ethyl (3R,4R,5S)-4-acetylamino-5-tert-butoxycarbonylamino-3-hydroxy-cyclohex-1-enecarboxylate
CAS No.:1137726-89-6
Molecular Formula:C₁₆H₂₆N₂O₆
Molecular Weight:342.392
Hs Code.:

Synonyms:ethyl (3R,4R,5S)-4-acetylamino-5-tert-butoxycarbonylamino-3-hydroxy-cyclohex-1-enecarboxylate

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Chemical Property of ethyl (3R,4R,5S)-4-acetylamino-5-tert-butoxycarbonylamino-3-hydroxy-cyclohex-1-enecarboxylate

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Technology Process of ethyl (3R,4R,5S)-4-acetylamino-5-tert-butoxycarbonylamino-3-hydroxy-cyclohex-1-enecarboxylate

There total 13 articles about ethyl (3R,4R,5S)-4-acetylamino-5-tert-butoxycarbonylamino-3-hydroxy-cyclohex-1-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1224161-52-7
(3aR,6S,7R,7aS)-7-acetylamino-6-tert-butoxycarbonylamino-2,2-dimethyl-3a,6,7,7a-tetrahydrobenzo[1,3]dioxole-4-carboxylic acid ethyl ester

: 1137726-89-6
ethyl (3R,4R,5S)-4-acetylamino-5-tert-butoxycarbonylamino-3-hydroxy-cyclohex-1-enecarboxylate

Guidance literature:: With ethanol; sodium ethanolate; at 20 ℃; for 0.0833333h; Inert atmosphere;
DOI:10.1002/adsc.200900844

Reference yield: 76.0%

: 1184177-26-1
tert-butyl (3aS,4R,5S,7S,7aR)-4-acetamido-7-((tert-butyldimethylsilyloxy)dicyanomethyl)-2,2-dimethyl-hexahydrobenzo[d][1,3]dioxol-5-ylcarbamate

: 1137726-89-6
ethyl (3R,4R,5S)-4-acetylamino-5-tert-butoxycarbonylamino-3-hydroxy-cyclohex-1-enecarboxylate

Guidance literature:: With ethanol; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine tris(hydrogen fluoride); at 20 ℃; for 36h;
DOI:10.1016/j.tet.2009.05.077

Reference yield:

: 64-17-5
ethanol

: 1137726-90-9
((1S,4S,5S)-4-acetamido-5-(tert-butoxycarbonylamino)cyclohex-2-enyl)dicyanomethyl acetate

: 1137726-89-6
ethyl (3R,4R,5S)-4-acetylamino-5-tert-butoxycarbonylamino-3-hydroxy-cyclohex-1-enecarboxylate

Guidance literature:: ((1S,4S,5S)-4-acetamido-5-(tert-butoxycarbonylamino)cyclohex-2-enyl)dicyanomethyl acetate; With disodium hydrogenphosphate; dihydrogen peroxide; urea; trifluoroacetic acid; In dichloromethane; at 4 ℃; for 2h; Inert atmosphere;

ethanol; With potassium carbonate; at 20 ℃; for 3h; Further stages; Inert atmosphere;
DOI:10.1002/anie.200804777