1137726-90-9Relevant academic research and scientific papers
A synthesis of tamiflu by using a barium-catalyzed asymmetric diels-alder-type reaction
Yamatsugu, Kenzo,Yin, Liang,Kamijo, Shin,Kimura, Yasuaki,Kanai, Motomu,Shibasaki, Masakatsu
, p. 1070 - 1076 (2009)
(Chemical Equation Presented) In pursuit of a better route: A new catalytic asymmetric synthesis of Tamiflu was developed. The key transformation was an asymmetric Diels-Alder-type reaction of 1 and 2 catalyzed by a barium/F 2-FujiCAPO complex in the presence of a CsF co-catalyst to construct the core of Tamiflu (see scheme; TMS=trimethylsilyl). The product was converted into Tamiflu in 11 steps on a gram scale.
