methyl (2S,4R)-4-[(tert-butoxycarbonyl)amino]-2-methyl-5-phenylpentanoate

Base Information

Chemical Name:methyl (2S,4R)-4-[(tert-butoxycarbonyl)amino]-2-methyl-5-phenylpentanoate
CAS No.:919518-38-0
Molecular Formula:C₁₈H₂₇NO₄
Molecular Weight:321.417
Hs Code.:

Synonyms:methyl (2S,4R)-4-[(tert-butoxycarbonyl)amino]-2-methyl-5-phenylpentanoate

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Chemical Property of methyl (2S,4R)-4-[(tert-butoxycarbonyl)amino]-2-methyl-5-phenylpentanoate

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Technology Process of methyl (2S,4R)-4-[(tert-butoxycarbonyl)amino]-2-methyl-5-phenylpentanoate

There total 17 articles about methyl (2S,4R)-4-[(tert-butoxycarbonyl)amino]-2-methyl-5-phenylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 368870-65-9
(2S,4R)-4-((tert-butoxycarbonyl)amino)-2-methyl-5-phenylpentanoic acid

: 74-88-4
methyl iodide

: 919518-38-0
methyl (2S,4R)-4-[(tert-butoxycarbonyl)amino]-2-methyl-5-phenylpentanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 22h;
DOI:10.1002/anie.201405650

Reference yield: 70.0%

: 919518-36-8
methyl (2S,4R)-4-[(tert-butoxycarbonyl)(p-toluenesulfonyl)amino]-2-methyl-5-phenylpentanoate

: 919518-38-0
methyl (2S,4R)-4-[(tert-butoxycarbonyl)amino]-2-methyl-5-phenylpentanoate

Guidance literature:: With magnesium; In tetrahydrofuran; methanol; for 2.3h; Heating; sonication;
DOI:10.1002/anie.200601259

Reference yield:

: 362495-90-7
[2S,4R]-(-)-2-methyl-5-phenyl-4-(p-toluenesulfonylamino)pentanoic acid

: 919518-38-0
methyl (2S,4R)-4-[(tert-butoxycarbonyl)amino]-2-methyl-5-phenylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / HCl / 16 h / Heating

2: 93 percent / DMAP / acetonitrile / 20 °C

3: 70 percent / Mg / tetrahydrofuran; methanol / 2.3 h / Heating; sonication

With hydrogenchloride; dmap; magnesium; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1002/anie.200601259