N-(3-((5-chloro-4-((2-(N-methylsulfamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide

Base Information

Chemical Name:N-(3-((5-chloro-4-((2-(N-methylsulfamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide
CAS No.:1346447-84-4
Molecular Formula:C₂₀H₁₉ClN₆O₃S
Molecular Weight:458.928
Hs Code.:

Synonyms:N-(3-((5-chloro-4-((2-(N-methylsulfamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide

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Chemical Property of N-(3-((5-chloro-4-((2-(N-methylsulfamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide

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Technology Process of N-(3-((5-chloro-4-((2-(N-methylsulfamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide

There total 6 articles about N-(3-((5-chloro-4-((2-(N-methylsulfamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.42%

: 1346447-83-3
2-((2-((3-aminophenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide

: 814-68-6,25189-84-8
acryloyl chloride

: 1346447-84-4
N-(3-((5-chloro-4-((2-(N-methylsulfamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.0166667h;

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 1346447-84-4
N-(3-((5-chloro-4-((2-(N-methylsulfamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane; methanol / 0.67 h / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

4: toluene-4-sulfonic acid / isopropyl alcohol / 5 h / 80 °C

5: hydrogen / platinum(IV) oxide / ethyl acetate / 2 h

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.02 h / 0 °C

With hydrogen; potassium carbonate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; palladium 10% on activated carbon; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 16288-77-0
2-amino-N-methylbenzenesulfonamide

: 1346447-84-4
N-(3-((5-chloro-4-((2-(N-methylsulfamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

2: toluene-4-sulfonic acid / isopropyl alcohol / 5 h / 80 °C

3: hydrogen / platinum(IV) oxide / ethyl acetate / 2 h

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.02 h / 0 °C

With hydrogen; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;