(2S,4S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-hexan-1-ol

Base Information

Chemical Name:(2S,4S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-hexan-1-ol
CAS No.:428874-29-7
Molecular Formula:C₂₄H₃₆O₂Si
Molecular Weight:384.634
Hs Code.:

Synonyms:(2S,4S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-hexan-1-ol

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Chemical Property of (2S,4S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-hexan-1-ol

Chemical Property:

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Technology Process of (2S,4S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-hexan-1-ol

There total 9 articles about (2S,4S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-hexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 428874-28-6
(S)-4-Benzyl-3-[(2S,4S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-hexanoyl]-oxazolidin-2-one

: 428874-29-7
(2S,4S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-hexan-1-ol

Guidance literature:: With lithium borohydride; In diethyl ether; at 0 ℃; for 0.5h;
DOI:10.1021/ja020091v

Reference yield:

: 253143-30-5
(R)-4-benzyl-3-((S)-2-ethylpent-4-enoyl)oxazolidin-2-one

: 428874-29-7
(2S,4S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-hexan-1-ol

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium borohydride / diethyl ether; H₂O / 0.5 h / 0 °C

2.1: 20.6 g / imidazole; 4 Angstroem molecular sieves / petroleum ether; diethyl ether; dimethylformamide / 20 °C

3.1: 9-BBN / tetrahydrofuran / 4 h / 20 °C

3.2: 92 percent / sodium hydroxide; hydroden peroxide / tetrahydrofuran; H₂O / 0 - 20 °C

4.1: pyridinium dichromate / CH₂Cl₂ / 0.5 h

5.1: 6.9 g / sodium chlorite; sulfamic acid / tetrahydrofuran; H₂O / 0 - 20 °C

6.1: triethylamine / tetrahydrofuran / -78 - 0 °C

7.1: 5.53 g / lithium chloride / tetrahydrofuran / 20 °C

8.1: sodium hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C

8.2: 95 percent / tetrahydrofuran / -78 - -40 °C

9.1: 90 percent / lithium borohydride / diethyl ether / 0.5 h / 0 °C

With 1H-imidazole; sodium chlorite; dipyridinium dichromate; lithium borohydride; 9-borabicyclo[3.3.1]nonane dimer; 4 A molecular sieve; aminosulfonic acid; sodium hexamethyldisilazane; triethylamine; lithium chloride; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; Petroleum ether;
DOI:10.1021/ja020091v

Reference yield:

: 253143-31-6
4-(tert-butyl-diphenyl-silanyloxymethyl)-hexan-1-ol

: 428874-29-7
(2S,4S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-hexan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridinium dichromate / CH₂Cl₂ / 0.5 h

2.1: 6.9 g / sodium chlorite; sulfamic acid / tetrahydrofuran; H₂O / 0 - 20 °C

3.1: triethylamine / tetrahydrofuran / -78 - 0 °C

4.1: 5.53 g / lithium chloride / tetrahydrofuran / 20 °C

5.1: sodium hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C

5.2: 95 percent / tetrahydrofuran / -78 - -40 °C

6.1: 90 percent / lithium borohydride / diethyl ether / 0.5 h / 0 °C

With sodium chlorite; dipyridinium dichromate; lithium borohydride; aminosulfonic acid; sodium hexamethyldisilazane; triethylamine; lithium chloride; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1021/ja020091v