(S)-5-{[(5-chloro-2-methylpyridin-3-yl)amino]methyl}-N-{3-cyclohexyl-1-[(2-hydroxyethyl)amino]-1-oxopropan-2-yl}thiophene-2-carboxamide

Base Information

Chemical Name:(S)-5-{[(5-chloro-2-methylpyridin-3-yl)amino]methyl}-N-{3-cyclohexyl-1-[(2-hydroxyethyl)amino]-1-oxopropan-2-yl}thiophene-2-carboxamide
CAS No.:1404456-26-3
Molecular Formula:C₂₃H₃₁ClN₄O₃S
Molecular Weight:479.043
Hs Code.:

Synonyms:(S)-5-{[(5-chloro-2-methylpyridin-3-yl)amino]methyl}-N-{3-cyclohexyl-1-[(2-hydroxyethyl)amino]-1-oxopropan-2-yl}thiophene-2-carboxamide

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Chemical Property of (S)-5-{[(5-chloro-2-methylpyridin-3-yl)amino]methyl}-N-{3-cyclohexyl-1-[(2-hydroxyethyl)amino]-1-oxopropan-2-yl}thiophene-2-carboxamide

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Technology Process of (S)-5-{[(5-chloro-2-methylpyridin-3-yl)amino]methyl}-N-{3-cyclohexyl-1-[(2-hydroxyethyl)amino]-1-oxopropan-2-yl}thiophene-2-carboxamide

There total 7 articles about (S)-5-{[(5-chloro-2-methylpyridin-3-yl)amino]methyl}-N-{3-cyclohexyl-1-[(2-hydroxyethyl)amino]-1-oxopropan-2-yl}thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1404456-63-8
5-{[(5-chloro-2-methyl-3-pyridinyl)amino]methyl}-2-thiophenecarboxylic acid

: (S)-2-amino-3-cyclohexyl-N-(2-hydroxyethyl)propanamide hydrochloride

: 1404456-26-3
(S)-5-{[(5-chloro-2-methylpyridin-3-yl)amino]methyl}-N-{3-cyclohexyl-1-[(2-hydroxyethyl)amino]-1-oxopropan-2-yl}thiophene-2-carboxamide

Guidance literature:: With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 21427-62-3
2,5-dichloro-3-nitropyridine

: 1404456-26-3
(S)-5-{[(5-chloro-2-methylpyridin-3-yl)amino]methyl}-N-{3-cyclohexyl-1-[(2-hydroxyethyl)amino]-1-oxopropan-2-yl}thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 3.83 h / 20 °C / Inert atmosphere

1.2: 12.5 h / Reflux

1.3: pH 9

2.1: tin(II) chloride dihdyrate / ethyl acetate / 3 h / 85 °C / Inert atmosphere

3.1: methanol / 2 h / 50 °C / Inert atmosphere

4.1: sodium cyanoborohydride / methanol / 14 h / 0 - 20 °C / Inert atmosphere

4.2: pH 4

5.1: 1-hydroxy-7-aza-benzotriazole; 4-methyl-morpholine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 4 h / 20 °C

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; tin(II) chloride dihdyrate; sodium hydride; sodium cyanoborohydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; mineral oil;

Reference yield:

: 37736-82-6
(S)-2-tert-butoxycarbonylamino-3-cyclohexylpropionic acid

: 1404456-26-3
(S)-5-{[(5-chloro-2-methylpyridin-3-yl)amino]methyl}-N-{3-cyclohexyl-1-[(2-hydroxyethyl)amino]-1-oxopropan-2-yl}thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 4-methyl-morpholine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 2 h / 20 °C

2: hydrogenchloride; water / dichloromethane / 2 h / 20 °C

3: 1-hydroxy-7-aza-benzotriazole; 4-methyl-morpholine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 4 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; water; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;