2-Thiophenecarboxylic acid, 5-[[(5-chloro-2-Methyl-3-pyridinyl)aMino]Methyl]-

Base Information

Chemical Name:2-Thiophenecarboxylic acid, 5-[[(5-chloro-2-Methyl-3-pyridinyl)aMino]Methyl]-
CAS No.:1404456-63-8
Molecular Formula:C12H11ClN2O2S
Molecular Weight:282.74594
Hs Code.:
Mol file:1404456-63-8.mol

Synonyms:2-Thiophenecarboxylic acid, 5-[[(5-chloro-2-Methyl-3-pyridinyl)aMino]Methyl]-;5-(((5-Chloro-2-methylpyridin-3-yl)amino)methyl)thiophene-2-carboxylic acid

Suppliers and Price of 2-Thiophenecarboxylic acid, 5-[[(5-chloro-2-Methyl-3-pyridinyl)aMino]Methyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
2-Thiophenecarboxylicacid,5-[[(5-chloro-2-methyl-3-pyridinyl)amino]methyl]-
500mg
$ 1500.00

Total 5 raw suppliers

Chemical Property of 2-Thiophenecarboxylic acid, 5-[[(5-chloro-2-Methyl-3-pyridinyl)aMino]Methyl]-

Chemical Property:

Boiling Point:486.1±45.0 °C(Predicted)
PKA:3.51±0.10(Predicted)
PSA：90.46000
Density:1.464±0.06 g/cm3(Predicted)
LogP:3.48820

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-Thiophenecarboxylicacid,5-[[(5-chloro-2-methyl-3-pyridinyl)amino]methyl]- ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Thiophenecarboxylic acid, 5-[[(5-chloro-2-Methyl-3-pyridinyl)aMino]Methyl]-

There total 4 articles about 2-Thiophenecarboxylic acid, 5-[[(5-chloro-2-Methyl-3-pyridinyl)aMino]Methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₉ClN₂O₂S

: 1404456-63-8
5-{[(5-chloro-2-methyl-3-pyridinyl)amino]methyl}-2-thiophenecarboxylic acid

Guidance literature:: C₁₂H₉ClN₂O₂S; With sodium cyanoborohydride; In methanol; at 0 - 20 ℃; for 14h; Inert atmosphere;

With hydrogenchloride; water; In methanol; pH=4;

Reference yield:

: 21427-62-3
2,5-dichloro-3-nitropyridine

: 1404456-63-8
5-{[(5-chloro-2-methyl-3-pyridinyl)amino]methyl}-2-thiophenecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 3.83 h / 20 °C / Inert atmosphere

1.2: 12.5 h / Reflux

1.3: pH 9

2.1: tin(II) chloride dihdyrate / ethyl acetate / 3 h / 85 °C / Inert atmosphere

3.1: methanol / 2 h / 50 °C / Inert atmosphere

4.1: sodium cyanoborohydride / methanol / 14 h / 0 - 20 °C / Inert atmosphere

4.2: pH 4

With tin(II) chloride dihdyrate; sodium hydride; sodium cyanoborohydride; In tetrahydrofuran; methanol; ethyl acetate; mineral oil;

Reference yield:

: 1211533-93-5
2-methyl-3-nitro-5-chloropyridine

: 1404456-63-8
5-{[(5-chloro-2-methyl-3-pyridinyl)amino]methyl}-2-thiophenecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tin(II) chloride dihdyrate / ethyl acetate / 3 h / 85 °C / Inert atmosphere

2.1: methanol / 2 h / 50 °C / Inert atmosphere

3.1: sodium cyanoborohydride / methanol / 14 h / 0 - 20 °C / Inert atmosphere

3.2: pH 4

With tin(II) chloride dihdyrate; sodium cyanoborohydride; In methanol; ethyl acetate;