ethyl 3-(6-(N-(2-(tert-butyldimethylsilyloxy)ethyl)methylsulfonamido)-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl)benzoate

Base Information

Chemical Name:ethyl 3-(6-(N-(2-(tert-butyldimethylsilyloxy)ethyl)methylsulfonamido)-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl)benzoate
CAS No.:1217340-54-9
Molecular Formula:C₃₄H₄₁FN₂O₇SSi
Molecular Weight:668.859
Hs Code.:

Synonyms:ethyl 3-(6-(N-(2-(tert-butyldimethylsilyloxy)ethyl)methylsulfonamido)-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl)benzoate

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Chemical Property of ethyl 3-(6-(N-(2-(tert-butyldimethylsilyloxy)ethyl)methylsulfonamido)-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl)benzoate

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Technology Process of ethyl 3-(6-(N-(2-(tert-butyldimethylsilyloxy)ethyl)methylsulfonamido)-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl)benzoate

There total 9 articles about ethyl 3-(6-(N-(2-(tert-butyldimethylsilyloxy)ethyl)methylsulfonamido)-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 691857-46-2
ethyl 2-(4-fluorophenyl)-5-hydroxy-6-nitrobenzofuran-3-carboxylate

: 1217340-54-9
ethyl 3-(6-(N-(2-(tert-butyldimethylsilyloxy)ethyl)methylsulfonamido)-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl)benzoate

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hydroxide; water / ethanol; tetrahydrofuran / 64 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

3: sodium hydroxide; water / ethanol / 70 °C

4: triethylamine / dichloromethane / 23 h / 0 - 20 °C / Inert atmosphere

5: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 90 °C

6: acetic acid; iron / ethanol / 1 h / 90 °C

7: pyridine / 20 - 25 °C

8: sodium carbonate / N,N-dimethyl-formamide / 20 - 100 °C

With pyridine; water; iron; sodium carbonate; caesium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1217340-48-1
2-(4-fluorophenyl)-5-hydroxy-6-nitrobenzofuran-3-carboxylic acid

: 1217340-54-9
ethyl 3-(6-(N-(2-(tert-butyldimethylsilyloxy)ethyl)methylsulfonamido)-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl)benzoate

Guidance literature:: Multi-step reaction with 7 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

2: sodium hydroxide; water / ethanol / 70 °C

3: triethylamine / dichloromethane / 23 h / 0 - 20 °C / Inert atmosphere

4: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 90 °C

5: acetic acid; iron / ethanol / 1 h / 90 °C

6: pyridine / 20 - 25 °C

7: sodium carbonate / N,N-dimethyl-formamide / 20 - 100 °C

With pyridine; water; iron; sodium carbonate; caesium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 691856-86-7
ethyl 2-(4-fluorophenyl)-5-hydroxybenzofuran-3-carboxylate

: 1217340-54-9
ethyl 3-(6-(N-(2-(tert-butyldimethylsilyloxy)ethyl)methylsulfonamido)-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl)benzoate

Guidance literature:: Multi-step reaction with 9 steps

1: nitric acid / chloroform / 0.17 h / 20 °C

2: sodium hydroxide; water / ethanol; tetrahydrofuran / 64 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

4: sodium hydroxide; water / ethanol / 70 °C

5: triethylamine / dichloromethane / 23 h / 0 - 20 °C / Inert atmosphere

6: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 90 °C

7: acetic acid; iron / ethanol / 1 h / 90 °C

8: pyridine / 20 - 25 °C

9: sodium carbonate / N,N-dimethyl-formamide / 20 - 100 °C

With pyridine; water; nitric acid; iron; sodium carbonate; caesium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;