di-tert-butyl {4-[bis(2-hydroxyethyl)amino]-2,3,5,6-tetrafluorobenzoyl}-L-glutamate

Base Information

Chemical Name:di-tert-butyl {4-[bis(2-hydroxyethyl)amino]-2,3,5,6-tetrafluorobenzoyl}-L-glutamate
CAS No.:863562-03-2
Molecular Formula:C₂₄H₃₄F₄N₂O₇
Molecular Weight:538.537
Hs Code.:

Synonyms:di-tert-butyl {4-[bis(2-hydroxyethyl)amino]-2,3,5,6-tetrafluorobenzoyl}-L-glutamate

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Chemical Property of di-tert-butyl {4-[bis(2-hydroxyethyl)amino]-2,3,5,6-tetrafluorobenzoyl}-L-glutamate

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Technology Process of di-tert-butyl {4-[bis(2-hydroxyethyl)amino]-2,3,5,6-tetrafluorobenzoyl}-L-glutamate

There total 3 articles about di-tert-butyl {4-[bis(2-hydroxyethyl)amino]-2,3,5,6-tetrafluorobenzoyl}-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 863562-01-0
di-tert-butyl pentafluorobenzoyl-L-glutamate

: 111-42-2
2,2'-iminobis[ethanol]

: 863562-03-2
di-tert-butyl {4-[bis(2-hydroxyethyl)amino]-2,3,5,6-tetrafluorobenzoyl}-L-glutamate

Guidance literature:: In N,N-dimethyl acetamide; at 85 ℃; for 144h;
DOI:10.1021/jm0502182

Reference yield:

pentafluorobenzoylchloride: 2251-50-5
pentafluorobenzoylchloride

: 863562-03-2
di-tert-butyl {4-[bis(2-hydroxyethyl)amino]-2,3,5,6-tetrafluorobenzoyl}-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / Et₃N / CH₂Cl₂

2: 61 percent / N,N-dimethyl-acetamide / 144 h / 85 °C

With triethylamine; In dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/jm0502182

Reference yield:

: 32677-01-3
L-glutamic acid di-tert-butyl ester hydrochloride

: 863562-03-2
di-tert-butyl {4-[bis(2-hydroxyethyl)amino]-2,3,5,6-tetrafluorobenzoyl}-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / Et₃N / CH₂Cl₂

2: 61 percent / N,N-dimethyl-acetamide / 144 h / 85 °C

With triethylamine; In dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/jm0502182