Technology Process of 4-amino-quinazoline-8-carboxylic acid [2,6-difluoro-3-(propane-1-sulfonylamino)phenyl]amide
There total 7 articles about 4-amino-quinazoline-8-carboxylic acid [2,6-difluoro-3-(propane-1-sulfonylamino)phenyl]amide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ammonia;
In
isopropyl alcohol;
at 105 ℃;
for 0.25h;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: methanol / 2 h / Cooling with water bath
2.1: hydrogen / palladium 10% on activated carbon / ethanol / Inert atmosphere
3.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with water bath
4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C
5.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / 20 - 80 °C
5.2: 15 h / 80 °C
6.1: magnesium sulfate; pyridine / chloroform / 1 h / 20 - 60 °C
7.1: ammonia / isopropyl alcohol / 0.25 h / 105 °C / Microwave irradiation
With
pyridine; methanol; diphenyl phosphoryl azide; ammonia; water; hydrogen; magnesium sulfate; triethylamine; sodium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; isopropyl alcohol;
5.2: Curtius Rearrangement;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrogen / palladium 10% on activated carbon / ethanol / Inert atmosphere
2.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with water bath
3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C
4.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / 20 - 80 °C
4.2: 15 h / 80 °C
5.1: magnesium sulfate; pyridine / chloroform / 1 h / 20 - 60 °C
6.1: ammonia / isopropyl alcohol / 0.25 h / 105 °C / Microwave irradiation
With
pyridine; diphenyl phosphoryl azide; ammonia; water; hydrogen; magnesium sulfate; triethylamine; sodium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; isopropyl alcohol;
4.2: Curtius Rearrangement;
