Technology Process of 4-chloro-N-(2,6-difluoro-3-(propylsulfonamido)phenyl)quinazoline-8-carboxamide
There total 6 articles about 4-chloro-N-(2,6-difluoro-3-(propylsulfonamido)phenyl)quinazoline-8-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine; magnesium sulfate;
In
chloroform;
at 20 - 60 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: methanol / 2 h / Cooling with water bath
2.1: hydrogen / palladium 10% on activated carbon / ethanol / Inert atmosphere
3.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with water bath
4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C
5.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / 20 - 80 °C
5.2: 15 h / 80 °C
6.1: magnesium sulfate; pyridine / chloroform / 1 h / 20 - 60 °C
With
pyridine; methanol; diphenyl phosphoryl azide; water; hydrogen; magnesium sulfate; triethylamine; sodium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform;
5.2: Curtius Rearrangement;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen / palladium 10% on activated carbon / ethanol / Inert atmosphere
2.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with water bath
3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C
4.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / 20 - 80 °C
4.2: 15 h / 80 °C
5.1: magnesium sulfate; pyridine / chloroform / 1 h / 20 - 60 °C
With
pyridine; diphenyl phosphoryl azide; water; hydrogen; magnesium sulfate; triethylamine; sodium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform;
4.2: Curtius Rearrangement;
