(2R,6S)-6-(3,4,5-trifluorophenyl)piperidine-2-carboxylic acid methyl ester

Base Information

Chemical Name:(2R,6S)-6-(3,4,5-trifluorophenyl)piperidine-2-carboxylic acid methyl ester
CAS No.:937399-85-4
Molecular Formula:C₁₃H₁₄F₃NO₂
Molecular Weight:273.255
Hs Code.:

Synonyms:(2R,6S)-6-(3,4,5-trifluorophenyl)piperidine-2-carboxylic acid methyl ester

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Chemical Property of (2R,6S)-6-(3,4,5-trifluorophenyl)piperidine-2-carboxylic acid methyl ester

Chemical Property:

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Technology Process of (2R,6S)-6-(3,4,5-trifluorophenyl)piperidine-2-carboxylic acid methyl ester

There total 4 articles about (2R,6S)-6-(3,4,5-trifluorophenyl)piperidine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 937399-84-3
methyl (R)-2-tert-butoxycarbonylamino-6-oxo-6-(3,4,5-trifluorophenyl)hexanoate

: 937399-85-4
(2R,6S)-6-(3,4,5-trifluorophenyl)piperidine-2-carboxylic acid methyl ester

Guidance literature:: methyl (R)-2-tert-butoxycarbonylamino-6-oxo-6-(3,4,5-trifluorophenyl)hexanoate; With hydrogenchloride; In ethyl acetate; at 20 ℃; for 14h;

With sodium hydrogencarbonate; In water; ethyl acetate;

With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃; for 6h;

Reference yield:

: 156006-28-9
3,4,5-trifluorophenylmagnesium bromide

: 183890-36-0
(R)-6-oxopiperidine-1,2-dicarboxylic acid 1-tertiary butyl ester 2-methyl ester

: 937399-85-4
(2R,6S)-6-(3,4,5-trifluorophenyl)piperidine-2-carboxylic acid methyl ester

Guidance literature:: 3,4,5-trifluorophenylmagnesium bromide; (R)-6-oxopiperidine-1,2-dicarboxylic acid 1-tertiary butyl ester 2-methyl ester; In tetrahydrofuran; at -78 - -10 ℃; for 2.5h;

With water; ammonium chloride; In tetrahydrofuran;

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; palladium 10% on activated carbon; more than 3 stages;

Reference yield:

: 138526-69-9
3,4,5-trifluoro-1-bromobenzene

: 937399-85-4
(2R,6S)-6-(3,4,5-trifluorophenyl)piperidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: magnesium / iodine / diethyl ether / 1 - 1.5 h / 20 °C / Heating / reflux

2: tetrahydrofuran / 2.5 h / -78 - -10 °C

With magnesium; iodine; In tetrahydrofuran; diethyl ether;