rac-2-[(2-tert-butyloxycarbonyl-aminoethyl)-(2-thymin-methyl-benzoyl)-amino]-3,3-dimethyl-butyric acid-(cyclohexen-1-yl)-amide

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Chemical Name:rac-2-[(2-tert-butyloxycarbonyl-aminoethyl)-(2-thymin-methyl-benzoyl)-amino]-3,3-dimethyl-butyric acid-(cyclohexen-1-yl)-amide
CAS No.:255736-71-1
Molecular Formula:C₃₂H₄₅N₅O₆
Molecular Weight:595.739
Hs Code.:

Synonyms:rac-2-[(2-tert-butyloxycarbonyl-aminoethyl)-(2-thymin-methyl-benzoyl)-amino]-3,3-dimethyl-butyric acid-(cyclohexen-1-yl)-amide

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Chemical Property of rac-2-[(2-tert-butyloxycarbonyl-aminoethyl)-(2-thymin-methyl-benzoyl)-amino]-3,3-dimethyl-butyric acid-(cyclohexen-1-yl)-amide

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Technology Process of rac-2-[(2-tert-butyloxycarbonyl-aminoethyl)-(2-thymin-methyl-benzoyl)-amino]-3,3-dimethyl-butyric acid-(cyclohexen-1-yl)-amide

There total 6 articles about rac-2-[(2-tert-butyloxycarbonyl-aminoethyl)-(2-thymin-methyl-benzoyl)-amino]-3,3-dimethyl-butyric acid-(cyclohexen-1-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 57260-73-8
N-BOC-1,2-diaminoethane

: 1121-57-9
1-isocyanocyclohexene

: 630-19-3
pivalaldehyde

: 255735-85-4
2-(thymin-1-yl)-methyl-benzoic acid

: 255736-71-1
rac-2-[(2-tert-butyloxycarbonyl-aminoethyl)-(2-thymin-methyl-benzoyl)-amino]-3,3-dimethyl-butyric acid-(cyclohexen-1-yl)-amide

Guidance literature:: In methanol; at 20 ℃; for 48h;
DOI:10.1016/S0968-0896(00)00066-3

Reference yield:

: 2417-73-4
methyl 2-bromomethylbenzoate

: 255736-71-1
rac-2-[(2-tert-butyloxycarbonyl-aminoethyl)-(2-thymin-methyl-benzoyl)-amino]-3,3-dimethyl-butyric acid-(cyclohexen-1-yl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dimethylformamide

2: 6.70 g / aq. NaOH / 48 h

3: 52 percent / methanol / 48 h / 20 °C

With sodium hydroxide; potassium carbonate; In methanol; N,N-dimethyl-formamide; 1: Alkylation / 2: Hydrolysis / 3: Ugi four component condensation;
DOI:10.1016/S0968-0896(00)00066-3

Reference yield:

: 40652-40-2
N-(cyclohexen-1-yl)formamide

: 255736-71-1
rac-2-[(2-tert-butyloxycarbonyl-aminoethyl)-(2-thymin-methyl-benzoyl)-amino]-3,3-dimethyl-butyric acid-(cyclohexen-1-yl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / phosgene; NEt₃ / CH₂Cl₂ / 1 h / 0 °C

2: 52 percent / methanol / 48 h / 20 °C

With phosgene; triethylamine; In methanol; dichloromethane; 1: Dehydration / 2: Ugi four component condensation;
DOI:10.1016/S0968-0896(00)00066-3