(+)-(2R,4R,4aR,7R,8aR)-2-(4-methoxyphenyl)-4,7-dimethyloctahydro-2H-cromen-4-ol

Base Information

• Chemical Name: (+)-(2R,4R,4aR,7R,8aR)-2-(4-methoxyphenyl)-4,7-dimethyloctahydro-2H-cromen-4-ol
• CAS No.: 1157856-34-2
• Molecular Formula: C₁₈H₂₆O₃
• Molecular Weight: 290.403

Synonyms:(+)-(2R,4R,4aR,7R,8aR)-2-(4-methoxyphenyl)-4,7-dimethyloctahydro-2H-cromen-4-ol

Chemical Property of (+)-(2R,4R,4aR,7R,8aR)-2-(4-methoxyphenyl)-4,7-dimethyloctahydro-2H-cromen-4-ol

Chemical Property:

Purity/Quality:

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Technology Process of (+)-(2R,4R,4aR,7R,8aR)-2-(4-methoxyphenyl)-4,7-dimethyloctahydro-2H-cromen-4-ol

There total 5 articles about (+)-(2R,4R,4aR,7R,8aR)-2-(4-methoxyphenyl)-4,7-dimethyloctahydro-2H-cromen-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isopulegol (7786-67-6,18674-65-2,20549-46-6,21290-09-5,29141-10-4,50373-36-9,59905-53-2,59905-54-3,96612-21-4,104870-56-6,121468-66-4,122517-60-6,122517-61-7,144541-38-8,89-79-2) + 4-methoxy-benzaldehyde (123-11-5) → (+)-(2R,4R,4aR,7R,8aR)-2-(4-methoxyphenyl)-4,7-dimethyloctahydro-2H-cromen-4-ol (1157856-34-2) + (2R,4S,4aR,7R,8aR)-4-fluoro-2-(4-methoxyphenyl)-4,7-dimethyloctahydro-2H-chromene + (2R,4R,4aR,7R,8aR)-4-fluoro-2-(4-methoxyphenyl)-4,7-dimethyloctahydro-2H-chromene

Guidance literature:

With boron trifluoride diethyl etherate; water; In dichloromethane; at 2 ℃; for 2.5h; chemoselective reaction;

DOI:10.1007/s10593-020-02743-z

Reference yield:

isopulegol (7786-67-6,18674-65-2,20549-46-6,21290-09-5,29141-10-4,50373-36-9,59905-53-2,59905-54-3,96612-21-4,104870-56-6,121468-66-4,122517-60-6,122517-61-7,144541-38-8,89-79-2) + 4-methoxy-benzaldehyde (123-11-5) → (+)-(2R,4R,4aR,7R,8aR)-2-(4-methoxyphenyl)-4,7-dimethyloctahydro-2H-cromen-4-ol (1157856-34-2) + (+)-(2R,4S,4aR,7R,8aR)-2-(4-methoxyphenyl)-4,7-dimethyloctahydro-2H-cromen-4-ol (1157856-35-3) + (2R,4S,4aR,7R,8aR)-4-fluoro-2-(4-methoxyphenyl)-4,7-dimethyloctahydro-2H-chromene + (2R,4R,4aR,7R,8aR)-4-fluoro-2-(4-methoxyphenyl)-4,7-dimethyloctahydro-2H-chromene

Guidance literature:

With boron trifluoride diethyl etherate; water; In dichloromethane; at 2 ℃; for 2.5h;

DOI:10.1016/j.bmcl.2020.127677

Reference yield:

isopulegol (7786-67-6,18674-65-2,20549-46-6,21290-09-5,29141-10-4,50373-36-9,59905-53-2,59905-54-3,96612-21-4,104870-56-6,121468-66-4,122517-60-6,122517-61-7,144541-38-8,89-79-2) + 4-methoxy-benzaldehyde (123-11-5) + benzonitrile (100-47-0) → (+)-(2R,4R,4aR,7R,8aR)-2-(4-methoxyphenyl)-4,7-dimethyloctahydro-2H-cromen-4-ol (1157856-34-2) + (+)-(2R,4S,4aR,7R,8aR)-2-(4-methoxyphenyl)-4,7-dimethyloctahydro-2H-cromen-4-ol (1157856-35-3) + C25H31NO3 (1638264-49-9) + C25H31NO3 (1638264-50-2)

Guidance literature:

With trifluorormethanesulfonic acid; In dichloromethane; at -25 - 0 ℃; for 1.25h;

DOI:10.1039/c4ra02124j

upstream raw materials:

isopulegol

4-methoxy-benzaldehyde

benzonitrile

acetonitrile

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