[2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl] acetate

Base Information

Chemical Name:[2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl] acetate
CAS No.:1429872-83-2
Molecular Formula:C₁₅H₁₃F₃N₂O₅S
Molecular Weight:390.34
Hs Code.:

Synonyms:[2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl] acetate

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Chemical Property of [2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl] acetate

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Technology Process of [2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl] acetate

There total 6 articles about [2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl] acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.78%

: 1429870-80-3
4-hydroxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]pyridazin-3-one

: 75-36-5
acetyl chloride

: 1429872-83-2
[2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl] acetate

Guidance literature:: 4-hydroxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]pyridazin-3-one; With pyridine; dmap; In dichloromethane; at 20 ℃; for 0.0333333h;

acetyl chloride; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 933-76-6
4,5-dichloro-2-methyl-3(2H)-pyridazinone

: 1429872-83-2
[2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl] acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,4-dioxane / 1 h / 20 °C

2.1: tricyclohexylphosphine; potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 150 °C / Microwave irradiation

3.1: cesium fluoride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.25 h / 160 °C / Microwave irradiation

4.1: dihydrogen peroxide; acetic acid / water / 55 °C

5.1: morpholine / 3 h / 100 °C

6.1: pyridine; dmap / dichloromethane / 0.03 h / 20 °C

6.2: 2 h / 20 °C

With morpholine; pyridine; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; dihydrogen peroxide; potassium acetate; acetic acid; cesium fluoride; tricyclohexylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 1429874-17-8
4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]pyridazin-3-one

: 1429872-83-2
[2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl] acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: morpholine / 3 h / 100 °C

2.1: pyridine; dmap / dichloromethane / 0.03 h / 20 °C

2.2: 2 h / 20 °C

With morpholine; pyridine; dmap; In dichloromethane;