(2R)-{[(1R)-2-hydroxy-1-phenylethyl]amino}(1-methylcyclohexyl)acetonitrile

Base Information

Chemical Name:(2R)-{[(1R)-2-hydroxy-1-phenylethyl]amino}(1-methylcyclohexyl)acetonitrile
CAS No.:923591-39-3
Molecular Formula:C₁₇H₂₄N₂O
Molecular Weight:272.39
Hs Code.:

Synonyms:(2R)-{[(1R)-2-hydroxy-1-phenylethyl]amino}(1-methylcyclohexyl)acetonitrile

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Chemical Property of (2R)-{[(1R)-2-hydroxy-1-phenylethyl]amino}(1-methylcyclohexyl)acetonitrile

Chemical Property:

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Technology Process of (2R)-{[(1R)-2-hydroxy-1-phenylethyl]amino}(1-methylcyclohexyl)acetonitrile

There total 6 articles about (2R)-{[(1R)-2-hydroxy-1-phenylethyl]amino}(1-methylcyclohexyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 7677-24-9
trimethylsilyl cyanide

: 6140-64-3
1-methylcyclohexanecarbaldehyde

: 923591-39-3
(2R)-{[(1R)-2-hydroxy-1-phenylethyl]amino}(1-methylcyclohexyl)acetonitrile

Guidance literature:: 1-methylcyclohexanecarbaldehyde; D-2-phenylglycinol; In chloroform; for 1h;

trimethylsilyl cyanide; In chloroform; at 0 - 20 ℃; for 48h;

With hydrogenchloride; sodium hydroxide; sodium hydrogencarbonate; more than 3 stages;

Reference yield:

: 1123-25-7
1-methyl-1-cyclohexanecarboxylic acid

: 923591-39-3
(2R)-{[(1R)-2-hydroxy-1-phenylethyl]amino}(1-methylcyclohexyl)acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: HCl / 16 h / Heating

2: LAH / CH₂Cl₂ / 16 h / -78 - 20 °C

3: PCC / CH₂Cl₂ / 16 h / 0 - 20 °C

4: CHCl₃ / 2 h / 20 °C

5: CHCl₃ / 16 h / 0 - 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; pyridinium chlorochromate; In dichloromethane; chloroform; 4: Strecker reaction / 5: Strecker reaction;
DOI:10.1016/j.tetlet.2007.07.002

Reference yield:

: 825-04-7
methyl 1-methylcyclohexanecarboxylate

: 923591-39-3
(2R)-{[(1R)-2-hydroxy-1-phenylethyl]amino}(1-methylcyclohexyl)acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: LAH / CH₂Cl₂ / 16 h / -78 - 20 °C

2: PCC / CH₂Cl₂ / 16 h / 0 - 20 °C

3: CHCl₃ / 2 h / 20 °C

4: CHCl₃ / 16 h / 0 - 20 °C

With lithium aluminium tetrahydride; pyridinium chlorochromate; In dichloromethane; chloroform; 3: Strecker reaction / 4: Strecker reaction;
DOI:10.1016/j.tetlet.2007.07.002