825-04-7

Usage

Uses

Used in Flavor and Fragrance Industry:
Cyclohexanecarboxylic acid, 1-methyl-, methyl ester is used as a flavoring agent and fragrance ingredient for its sweet, citrus-like aroma, adding pleasant scents to various products.
Used in Industrial Applications:
As a solvent, cyclohexanecarboxylic acid, 1-methyl-, methyl ester is utilized in various industrial processes, contributing to the efficiency and performance of different products.
Used in Pharmaceutical Industry:
Cyclohexanecarboxylic acid, 1-methyl-, methyl ester has been studied for its potential use in pharmaceuticals, indicating its possible role in the development of new medications.
Used in Organic Synthesis:
As a precursor in organic synthesis, cyclohexanecarboxylic acid, 1-methyl-, methyl ester plays a crucial role in the creation of other chemical compounds, expanding its applications in the chemical industry.

Upstream product

• 67-56-1 methanol 
• 1892-09-7 2-chloro-1-cyclohexyl-1-ethanone 
• 124-41-4 sodium methylate 
• 60-29-7 diethyl ether 
• 56077-27-1 1-(1-bromocyclohexyl)ethan-1-one 
• 14064-13-2 (1-methylcyclohexyl)methanol 
• 4630-82-4 methyl cyclohexylcarboxylate 
• 74-88-4 methyl iodide 
• 1123-25-7 1-methyl-1-cyclohexanecarboxylic acid 
• 61985-23-7 methyl 1-imidazolecarboxylate 
• 56078-05-8 Methyl-1-(2',2'-dimethoxyethyl)-cyclohexan-1-carboxylat 
• 41487-74-5 2,2-Dibromospiro<3,5>nonan-1-on 
• 41487-75-6 Methyl-1-(2',2'-dibrom-ethyl)-cyclohexan-1-carboxylat 
• 111-24-0 1,5-dibromo-pentane 

Downstream Products

• 14064-13-2 (1-methylcyclohexyl)methanol 
• 75621-17-9 (1-methylcyclohexyl)methan-d2-ol 
• 70869-87-3 trifluoromethanesulfonic acid 1-methyl-cyclohexylmethyl ester 
• 75621-18-0 (1-methylcyclohexyl)methyl-d2 triflate 
• 1337931-74-4 3-(1-methylcyclohexyl)-1-(p-tolyl)-1H-pyrazol-5-amine 
• 56294-19-0 methyl 1-methyl-3-oxocyclohexane-1-carboxylate 
• 37480-41-4 methyl 1-methyl-4-oxo-1-cyclohexanecarboxylate 
• 1429896-59-2 1-methyl-N-(quinolin-8-yl)cyclohexane-1-carboxamide 
• 2890-61-1 1-methyl-1-cyclohexancarboxylic acid chloride 
• 1360568-84-8 (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-((1-methylcyclohexyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol 
• 1360568-83-7 4-bromo-1-chloro-2-(4-((1-methylcyclohexyl)methoxy)benzyl)benzene 
• 14064-12-1 (1-methylcyclohexyl)methyl-4-methylbenzenesulfonate 
• 95882-32-9 3-(1-methylcyclohexyl)-3-oxopropanenitrile 
• 91138-78-2 1-(α-Chlor-isopropyl)-1-methyl-cyclohexan 

Relevant academic research and scientific papers

Nickel-catalysed direct alkylation of thiophenes via double C(sp3)-H/C(sp2)-H bond cleavage: The importance of KH2PO4

A Ni-catalyzed oxidative C-H/C-H cross-dehydrogenative coupling (CDC) reaction was developed for constructing various highly functionalized alkyl (aryl)-substituted thiophenes. This method employs thiophenes and aliphatic (aromatic) amides that contain an 8-aminoquinoline as a removable directing group in the presence of a silver oxidant. The approach enables the facile one-step synthesis of substituted thiophenes with high functional group compatibility via double C-H bond cleavage without affecting C-Br and C-I bonds. DFT calculations verify the importance of KH2PO4 as an additive for promoting C-H bond cleavage and support the involvement of a Ni(iii) species in the reaction.

Nickel-Catalyzed Addition-Type Alkenylation of Unactivated, Aliphatic C-H Bonds with Alkynes: A Concise Route to Polysubstituted γ-Butyrolactones

(Chemical Equation Presented). Through the nickel-catalyzed chelation-assisted C-H bond activation strategy, the addition-type alkenylation of unreactive β-C(sp3)-H bonds of aliphatic amides with internal alkynes is developed for the first time to produce γ,δ-unsaturated carboxylic amide derivatives. The resulting alkenylated products can further be transformed into polysubstituted γ-butyrolactones with pyridinium chlorochromate (PCC).

CYCLOALKYL METHOXYBENZYL PHENYL PYRAN DERIVATIVES AS SODIUM DEPENDENT GLUCOSE CO TRANSPORTER (SGLT2) INHIBITORS

The invention relates to the cycloalkyl methoxybenzyl phenyl pyran derivatives as Sodium dependent glucose co transporter (SGLT) inhibitors, particularly SGLT2 and method of treating diseases, conditions and/or disorders inhibited by SGLT2 with them, and processes for preparing them.

Chemoselective esterification and amidation of carboxylic acids with imidazole carbamates and ureas

Imidazole carbamates and ureas were found to be chemoselective esterification and amidation reagents. A wide variety of carboxylic acids were converted to their ester or amide analogues by a simple synthetic procedure in high yields.

Practical and efficient method for amino acid derivatives containing β-quaternary center: application toward synthesis of hepatitis C virus NS3 serine protease inhibitors

A practical and efficient route toward synthesis of amino acid derivatives containing β-quaternary center has been developed using diastereoselective Strecker reaction. The method was employed for preparation of >100 g of β-methylcyclohexyl glycine deriva

Design and synthesis of novel imidazoline derivatives with potent antihyperglycemic activity in a rat model of type 2 diabetes

Imidazoline derivatives have been reported to show antihyperglycemic activity in vivo. In the present study, we first showed that there was no correlation between the in vivo antidiabetic activity and the in vitro affinities for the I1/I2

NOVEL KETOAMIDES WITH CYCLIC P4'S AS INHIBITORS OF NS3 SERINE PROTEASE OF HEPATITIS C VIRUS

The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

NOVEL COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE

The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

CYCLOBUTENEDIONE GROUPS-CONTAINING COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE

The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

NOVEL COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE

The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.