8-methyl-N-(4-methylthiazol-2-yl)-6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxamide

Base Information

Chemical Name:8-methyl-N-(4-methylthiazol-2-yl)-6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxamide
CAS No.:1303585-26-3
Molecular Formula:C₂₀H₁₇F₃N₄O₂S
Molecular Weight:434.442
Hs Code.:

Synonyms:8-methyl-N-(4-methylthiazol-2-yl)-6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxamide

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Chemical Property of 8-methyl-N-(4-methylthiazol-2-yl)-6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxamide

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Technology Process of 8-methyl-N-(4-methylthiazol-2-yl)-6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxamide

There total 9 articles about 8-methyl-N-(4-methylthiazol-2-yl)-6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.1%

: 1603-91-4
4-methylthiazol-2-ylamine

: 32315-10-9
bis(trichloromethyl) carbonate

: 1303587-95-2
8-methyl-6-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

: 1303585-26-3
8-methyl-N-(4-methylthiazol-2-yl)-6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 1003-67-4
4-methylpyridine-1-oxide

: 1303585-26-3
8-methyl-N-(4-methylthiazol-2-yl)-6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: 2 h / Reflux

2.1: potassium hydroxide / methanol / 20 °C

2.2: pH 7

3.1: nitric acid; sulfuric acid / 2 h / 10 - 20 °C

3.2: pH 2

4.1: sodium methylate / methanol / 0.25 h / 20 °C

4.2: 2 h / 0 °C

5.1: potassium carbonate / dimethyl sulfoxide / 24 h / 30 °C

6.1: calcium chloride; iron / ethanol; water / 8 h / Reflux

7.1: dimethylsulfide borane complex / tetrahydrofuran / Reflux

7.2: Reflux

8.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / 120 °C / Inert atmosphere; sealed tube

9.1: triethylamine / dichloromethane / 20 °C

With dimethylsulfide borane complex; sulfuric acid; nitric acid; sodium methylate; iron; sodium carbonate; potassium carbonate; triethylamine; calcium chloride; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 15128-89-9
2-nitro-3-hydroxy-4-methylpyridine

: 1303585-26-3
8-methyl-N-(4-methylthiazol-2-yl)-6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium methylate / methanol / 0.25 h / 20 °C

1.2: 2 h / 0 °C

2.1: potassium carbonate / dimethyl sulfoxide / 24 h / 30 °C

3.1: calcium chloride; iron / ethanol; water / 8 h / Reflux

4.1: dimethylsulfide borane complex / tetrahydrofuran / Reflux

4.2: Reflux

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / 120 °C / Inert atmosphere; sealed tube

6.1: triethylamine / dichloromethane / 20 °C

With dimethylsulfide borane complex; sodium methylate; iron; sodium carbonate; potassium carbonate; triethylamine; calcium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide;