2-(5-((5-(4-chlorophenyl)furan-2-yl)-methylene)-4-oxo-2-thioxo thiazolidin-3-yl)-N-butylacetamide

Base Information

• Chemical Name: 2-(5-((5-(4-chlorophenyl)furan-2-yl)-methylene)-4-oxo-2-thioxo thiazolidin-3-yl)-N-butylacetamide
• CAS No.: 1152541-61-1
• Molecular Formula: C₂₀H₁₉ClN₂O₃S₂
• Molecular Weight: 434.967

Synonyms:2-(5-((5-(4-chlorophenyl)furan-2-yl)-methylene)-4-oxo-2-thioxo thiazolidin-3-yl)-N-butylacetamide

Chemical Property of 2-(5-((5-(4-chlorophenyl)furan-2-yl)-methylene)-4-oxo-2-thioxo thiazolidin-3-yl)-N-butylacetamide

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Technology Process of 2-(5-((5-(4-chlorophenyl)furan-2-yl)-methylene)-4-oxo-2-thioxo thiazolidin-3-yl)-N-butylacetamide

There total 3 articles about 2-(5-((5-(4-chlorophenyl)furan-2-yl)-methylene)-4-oxo-2-thioxo thiazolidin-3-yl)-N-butylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-(5-((5-(4-chlorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid (259811-65-9) + N-butylamine (109-73-9,85404-21-3) → 2-(5-((5-(4-chlorophenyl)furan-2-yl)-methylene)-4-oxo-2-thioxo thiazolidin-3-yl)-N-butylacetamide (1152541-61-1)

Guidance literature:

2-(5-((5-(4-chlorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid; With tert-butyl chloroformate; triethylamine; In tetrahydrofuran; at 0 - 5 ℃; for 0.25h;

N-butylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmc.2009.01.016

Reference yield:

5-(4-chlorophenyl)-2-furaldehyde (34035-03-5) → 2-(5-((5-(4-chlorophenyl)furan-2-yl)-methylene)-4-oxo-2-thioxo thiazolidin-3-yl)-N-butylacetamide (1152541-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate; acetic acid / 10 h / 120 °C

2: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 5 h / 20 °C

With 4-methyl-morpholine; sodium acetate; acetic acid; HATU; In N,N-dimethyl-formamide;

DOI:10.1007/s00044-009-9187-7

Reference yield:

rhodanine 3-acetic acid (5718-83-2) → 2-(5-((5-(4-chlorophenyl)furan-2-yl)-methylene)-4-oxo-2-thioxo thiazolidin-3-yl)-N-butylacetamide (1152541-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate; acetic acid / 10 h / 120 °C

2: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 5 h / 20 °C

With 4-methyl-morpholine; sodium acetate; acetic acid; HATU; In N,N-dimethyl-formamide;

DOI:10.1007/s00044-009-9187-7

upstream raw materials:

2-(5-((5-(4-chlorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid

N-butylamine

5-(4-chlorophenyl)-2-furaldehyde

rhodanine 3-acetic acid

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