2-Chloro-3-methoxyquinoxaline

Base Information

• Chemical Name: 2-Chloro-3-methoxyquinoxaline
• CAS No.: 32998-25-7
• Molecular Formula: C9H7 Cl N2 O
• Molecular Weight: 194.62
• Hs Code.: 2933990090
• European Community (EC) Number: 692-829-5
• DSSTox Substance ID: DTXSID30603846
• Wikidata: Q72453541
• Mol file: 32998-25-7.mol

Synonyms:2-Chloro-3-methoxyquinoxaline;32998-25-7;2-Chloro-3-methoxy-quinoxaline;Quinoxaline, 2-chloro-3-methoxy-;SCHEMBL2178510;DTXSID30603846;2-chloranyl-3-methoxy-quinoxaline;TTXKLKHPMYZIAE-UHFFFAOYSA-N;MFCD07367979;AKOS006287246;AB31541;FS-3244;AC-14398;AM100667;DB-027922;A821557;J-018968

Chemical Property of 2-Chloro-3-methoxyquinoxaline

Chemical Property:

• Vapor Pressure: 0.0112mmHg at 25°C
• Melting Point: 71-75℃
• Refractive Index: 1.628
• Boiling Point: 270.7°Cat760mmHg
• Flash Point: 117.5°C
• PSA: 35.01000
• Density: 1.333g/cm³
• LogP: 2.29180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 194.0246905
• Heavy Atom Count: 13
• Complexity: 179

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-3-methoxyquinoxaline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC2=CC=CC=C2N=C1Cl

Technology Process of 2-Chloro-3-methoxyquinoxaline

There total 11 articles about 2-Chloro-3-methoxyquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methanol (67-56-1) + 2,3-dichloroquinoxaline (2213-63-0) + sodium methylate (124-41-4) → 2-chloro-3-methoxyquinoxaline (32998-25-7)

Guidance literature:

In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield: 86.0%

2,3-dichloroquinoxaline (2213-63-0) + sodium methylate (124-41-4) → 2-chloro-3-methoxyquinoxaline (32998-25-7)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 1.5h;

DOI:10.3390/molecules17077737

Reference yield: 85.0%

methanol (67-56-1) + 2,3-dichloroquinoxaline (2213-63-0) → 2-chloro-3-methoxyquinoxaline (32998-25-7)

Guidance literature:

methanol; With sodium; at 20 ℃; for 0.25h;

2,3-dichloroquinoxaline; at 20 ℃;

DOI:10.1016/j.tet.2016.08.067

upstream raw materials:

2,3-dichloroquinoxaline

sodium methylate

2-chloro-3-nitroquinoxaline

2-amino-3-chloroquinoxaline

Downstream raw materials:

3-Methoxy-chinoxalin-2-on

1-(3-methoxyquinoxalin-2-ylmethyl)-3-phenylurea

N-(3-methoxyquinoxalin-2-ylmethyl)benzamide

4-chloro-1-(2-chlorophenyl)-[1,2,4]triazolo[4,3-a]quinoxaline

Refernces

• 1、 Keivanloo, Ali,Soozani, Atena,Bakherad, Mohammad,Mirzaee, Mahdi,Rudbari, Hadi Amiri,Bruno, Giuseppe. "Development of an unexpected reaction pathway for the synthesis of 1,2,4-trisubstituted pyrrolo[1,2-a]quinoxalines through palladium-catalyzed cascade reactions". . p. 1633 - 1639. Retrieved 2017.
• 2、 Chandra Sekhar, Kondapalli Venkata Gowri,Rao, Vajja Sambasiva,Deuther-Conrad, Winnie,Sridhar, Divya,Nagesh, Hunsur Nagendra,Kumar, Vellas Sreedhar,Brust, Peter,Kumar, Muthyala Murali Krishna. "Design, synthesis, and preliminary in vitro and in vivo pharmacological evaluation of 4-{4-[2-(4-(2-substitutedquinoxalin-3-yl)piperazin-1-yl)ethyl] phenyl}thiazoles as atypical antipsychotic agents". . p. 1660 - 1673. Retrieved 2013/07/26.