ethyl 4-oxo-7-phenylheptanoate

Base Information

• Chemical Name: ethyl 4-oxo-7-phenylheptanoate
• CAS No.: 108972-13-0
• Molecular Formula: C₁₅H₂₀O₃
• Molecular Weight: 248.322
• Mol file: 108972-13-0.mol

Synonyms:ethyl 4-oxo-7-phenylheptanoate

Chemical Property of ethyl 4-oxo-7-phenylheptanoate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl 4-oxo-7-phenylheptanoate

There total 15 articles about ethyl 4-oxo-7-phenylheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

ethyl 3-(chloroformyl)propionate (14794-31-1,97900-84-0) + 1,3-dioxoisoindolin-2-yl 4-phenylbutanoate (1841512-58-0) → ethyl 4-oxo-7-phenylheptanoate (108972-13-0)

Guidance literature:

With 4,4'-di-tert-butyl-2,2'-bipyridine nickel(II) bromide; zinc; In N,N-dimethyl acetamide; at 28 ℃; for 1h; Inert atmosphere; Glovebox;

DOI:10.1021/jacs.6b01533

Reference yield: 78.0%

ethyl 4-oxo-4-(pyridin-2-ylthio)butanoate (1361492-39-8) + 1,3-dioxoisoindolin-2-yl 4-phenylbutanoate (1841512-58-0) → ethyl 4-oxo-7-phenylheptanoate (108972-13-0)

Guidance literature:

With nickel(II) bromide dimethoxyethane; 4,4'-bis(carbomethoxy)-2,2'-bipyridine; zinc(II) chloride; zinc; In tetrahydrofuran; N,N-dimethyl acetamide; at 20 ℃; for 24h; Reagent/catalyst; Solvent; Catalytic behavior; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201906000

Reference yield: 50.0%

ethyl 2-(ethoxythiocarbonylthio)acetate (3278-34-0) + 2-[(2-ethoxy-5-phenylpent-1-en-3-yl)oxy]-6-fluoropyridine (1337568-61-2) → ethyl 4-oxo-7-phenylheptanoate (108972-13-0)

Guidance literature:

ethyl 2-(ethoxythiocarbonylthio)acetate; 2-[(2-ethoxy-5-phenylpent-1-en-3-yl)oxy]-6-fluoropyridine; With dilauryl peroxide; In ethyl acetate; Inert atmosphere; Reflux;

With hydrogenchloride; water; In ethyl acetate; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol202399c

upstream raw materials:

2-(1-hydroxy-3-phenylpropyl)-furan

ethanol

hydrogenchloride

ethyl 3-(chloroformyl)propionate

Downstream raw materials:

7-phenyl-heptane-1,4-diol

4-oxo-7-phenylheptanoic acid