1841512-58-0Relevant articles and documents
Expanding Reactivity in DNA-Encoded Library Synthesis via Reversible Binding of DNA to an Inert Quaternary Ammonium Support
Flood, Dillon T.,Asai, Shota,Zhang, Xuejing,Wang, Jie,Yoon, Leonard,Adams, Zo? C.,Dillingham, Blythe C.,Sanchez, Brittany B.,Vantourout, Julien C.,Flanagan, Mark E.,Piotrowski, David W.,Richardson, Paul,Green, Samantha A.,Shenvi, Ryan A.,Chen, Jason S.,Baran, Phil S.,Dawson, Philip E.
, p. 9998 - 10006 (2019)
DNA Encoded Libraries have proven immensely powerful tools for lead identification. The ability to screen billions of compounds at once has spurred increasing interest in DEL development and utilization. Although DEL provides access to libraries of unprec
Photoinduced Decarboxylative Phosphorothiolation of N-Hydroxyphthalimide Esters
Guo, Yu,Luo, Ying,Mu, Shiqiang,Xu, Jian,Song, Qiuling
supporting information, p. 6729 - 6734 (2021/09/11)
A visible-light-induced protocol for the synthesis of phosphorothioates is developed by employing the Ir-catalyzed decarboxylative phosphorothiolation of N-hydroxyphthalimide esters. This novel synthesis method utilizes carboxylic acids as raw material, which is stable, cheap, and commercially available. Scope studies show that this reaction has good compatibility of functional groups. Notably, both the synthesis of steric hindrance phosphorothioates and the later modification of some bioactive compounds are successfully achieved.
Photodecarboxylative Amination of Redox-Active Esters with Diazirines
Maharaj, Vishala,Chandrachud, Preeti P.,Che, Wen,Wojtas, Lukasz,Lopchuk, Justin M.
supporting information, p. 8838 - 8842 (2021/11/24)
Diazirines have been recently demonstrated to serve as electrophilic amination reagents that afford diaziridines, versatile heterocycles that are readily transformed into amines, hydrazines, and nitrogen-containing heterocycles. Here, we report the photodecarboxylative amination of redox-active esters with diazirines using inexpensive photoactivators under mild conditions with an enhanced scope for primary substrates. The stability of diazirines to blue light is demonstrated, paving the way for further research into other photochemical amination methods with these unique heterocycles.
