5-benzyloxy-2-bromo-4,β-dimethoxystyrene

Base Information

• Chemical Name: 5-benzyloxy-2-bromo-4,β-dimethoxystyrene
• CAS No.: 163595-81-1
• Molecular Formula: C₁₇H₁₇BrO₃
• Molecular Weight: 349.224
• Mol file: 163595-81-1.mol

Synonyms:5-benzyloxy-2-bromo-4,β-dimethoxystyrene

Chemical Property of 5-benzyloxy-2-bromo-4,β-dimethoxystyrene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-benzyloxy-2-bromo-4,β-dimethoxystyrene

There total 3 articles about 5-benzyloxy-2-bromo-4,β-dimethoxystyrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.8%

5-benzyloxy-2-bromo-4-methoxybenzaldehyde (6451-86-1) + (methoxymethyl)triphenylphosphonium chloride (4009-98-7) → 5-benzyloxy-2-bromo-4,β-dimethoxystyrene (163595-81-1)

Guidance literature:

With sodium t-butanolate; In dichloromethane; Cooling with ice; Inert atmosphere;

Reference yield:

benzyl bromide (100-39-0) → 5-benzyloxy-2-bromo-4,β-dimethoxystyrene (163595-81-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile / 60 °C

1.2: 6 h / 60 °C

2.1: sodium t-butanolate / dichloromethane / Cooling with ice; Inert atmosphere

With potassium carbonate; sodium t-butanolate; In dichloromethane; acetonitrile;

Reference yield:

2-bromoisovanillin (2973-59-3) → 5-benzyloxy-2-bromo-4,β-dimethoxystyrene (163595-81-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile / 60 °C

1.2: 6 h / 60 °C

2.1: sodium t-butanolate / dichloromethane / Cooling with ice; Inert atmosphere

With potassium carbonate; sodium t-butanolate; In dichloromethane; acetonitrile;

upstream raw materials:

5-benzyloxy-2-bromo-4-methoxybenzaldehyde

(methoxymethyl)triphenylphosphonium chloride

2-bromoisovanillin

benzyl bromide

Downstream raw materials:

(5-benzyloxy-2-bromo-4-methoxyphenyl)acetaldehyde dimethyl acetal

4-benzyloxy-5-methoxy-2-(2-methoxyethenyl)benzaldehyde

2-(5-benzyloxy-2-bromo-4-methoxyphenyl)ethanol

methyl 6-benzyloxy-4-(2,2-dimethoxyethyl)-7-methoxyindole-2-carboxylate