2-methyl-3-[5-(4-phenyl-1-piperazinyl)pentyl]-4(3H)-quinazolinone

Base Information

• Chemical Name: 2-methyl-3-[5-(4-phenyl-1-piperazinyl)pentyl]-4(3H)-quinazolinone
• CAS No.: 5193-50-0
• Molecular Formula: C₂₄H₃₀N₄O
• Molecular Weight: 390.528
• Mol file: 5193-50-0.mol

Synonyms:2-methyl-3-[5-(4-phenyl-1-piperazinyl)pentyl]-4(3H)-quinazolinone

Chemical Property of 2-methyl-3-[5-(4-phenyl-1-piperazinyl)pentyl]-4(3H)-quinazolinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-3-[5-(4-phenyl-1-piperazinyl)pentyl]-4(3H)-quinazolinone

There total 3 articles about 2-methyl-3-[5-(4-phenyl-1-piperazinyl)pentyl]-4(3H)-quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

4-phenyl-1-piperazine (92-54-6) + 3-(5-bromopentyl)-2-methyl-4(3H)-quinazolinone → 2-methyl-3-[5-(4-phenyl-1-piperazinyl)pentyl]-4(3H)-quinazolinone (5193-50-0)

Guidance literature:

With sodium carbonate; potassium iodide; In acetonitrile; at 90 ℃; for 1h; Sealed tube; Microwave irradiation;

DOI:10.1016/j.bmc.2016.12.039

Reference yield:

2-methyl-4-quinazolone (1769-24-0) → 2-methyl-3-[5-(4-phenyl-1-piperazinyl)pentyl]-4(3H)-quinazolinone (5193-50-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / acetonitrile / 1.5 h / 90 °C / Sealed tube; Microwave irradiation

2: potassium iodide; sodium carbonate / acetonitrile / 1 h / 90 °C / Sealed tube; Microwave irradiation

With sodium carbonate; potassium carbonate; potassium iodide; In acetonitrile;

DOI:10.1016/j.bmc.2016.12.039

Reference yield:

→ 2-methyl-3-[5-(4-phenyl-1-piperazinyl)pentyl]-4(3H)-quinazolinone (5193-50-0)

Guidance literature:

entspr. Benzoxazin II, entspr. Alkylamin;

upstream raw materials:

4-phenyl-1-piperazine

2-methyl-4-quinazolone