benzyl 5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-ylcarbamate

Base Information

Chemical Name:benzyl 5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-ylcarbamate
CAS No.:1199829-04-3
Molecular Formula:C₂₃H₂₂F₃N₃O₃
Molecular Weight:445.441
Hs Code.:

Synonyms:benzyl 5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-ylcarbamate

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Chemical Property of benzyl 5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-ylcarbamate

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Technology Process of benzyl 5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-ylcarbamate

There total 8 articles about benzyl 5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.1%

: 1199829-02-1
ethyl 1-((1-(benzyloxycarbonylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 1199829-04-3
benzyl 5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-ylcarbamate

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2010.11.098

Reference yield:

: 185122-74-1
5-bromo-2,3-dihydro-1H-inden-1-one oxime

: 1199829-04-3
benzyl 5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-ylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / water; ethyl acetate

2: 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl / methanol; acetonitrile / 0.5 h / 150 °C / Irradiation with microwave

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

4: thionyl chloride / dichloromethane / 2 h / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

6: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

With lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1199828-97-1
benzyl 5-bromo-2,3-dihydro-1H-inden-1-ylcarbamate

: 1199829-04-3
benzyl 5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl / methanol; acetonitrile / 0.5 h / 150 °C / Irradiation with microwave

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

3: thionyl chloride / dichloromethane / 2 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

5: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

With lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;