ethyl 1-((1-(benzyloxycarbonylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Base Information

Chemical Name:ethyl 1-((1-(benzyloxycarbonylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate
CAS No.:1199829-02-1
Molecular Formula:C₂₅H₂₄F₃N₃O₄
Molecular Weight:487.478
Hs Code.:

Synonyms:ethyl 1-((1-(benzyloxycarbonylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate

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Chemical Property of ethyl 1-((1-(benzyloxycarbonylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate

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Technology Process of ethyl 1-((1-(benzyloxycarbonylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate

There total 7 articles about ethyl 1-((1-(benzyloxycarbonylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1251457-86-9
benzyl 5-(chloromethyl)-2,3-dihydro-1H-inden-1-ylcarbamate

: 155377-19-8
ethyl 3-trifluoromethyl-1H-pyrazole-4-carboxylate

: 1199829-02-1
ethyl 1-((1-(benzyloxycarbonylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: With potassium carbonate; at 60 ℃;
DOI:10.1016/j.bmcl.2010.11.098

Reference yield:

: 185122-74-1
5-bromo-2,3-dihydro-1H-inden-1-one oxime

: 1199829-02-1
ethyl 1-((1-(benzyloxycarbonylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / water; ethyl acetate

2: 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl / methanol; acetonitrile / 0.5 h / 150 °C / Irradiation with microwave

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

4: thionyl chloride / dichloromethane / 2 h / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

With lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1199828-97-1
benzyl 5-bromo-2,3-dihydro-1H-inden-1-ylcarbamate

: 1199829-02-1
ethyl 1-((1-(benzyloxycarbonylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl / methanol; acetonitrile / 0.5 h / 150 °C / Irradiation with microwave

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

3: thionyl chloride / dichloromethane / 2 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

With lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;