3-Pyridinamine, N-methyl-2-nitro-

Base Information

• Chemical Name: 3-Pyridinamine, N-methyl-2-nitro-
• CAS No.: 32605-06-4
• Molecular Formula: C₆H₇N₃O₂
• Molecular Weight: 153.14
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID401303986
• Nikkaji Number: J465.175H
• Mol file: 32605-06-4.mol

Synonyms:Pyridine,3-(methylamino)-2-nitro- (6CI,8CI); 2-Nitro-3-(methylamino)pyridine;3-(Methylamino)-2-nitropyridine; N-Methyl-2-nitropyridin-3-amine

Chemical Property of 3-Pyridinamine, N-methyl-2-nitro-

Chemical Property:

• Vapor Pressure: 0.000116mmHg at 25°C
• Refractive Index: 1.629
• Boiling Point: 335.9°C at 760 mmHg
• Flash Point: 157°C
• PSA: 70.74000
• Density: 1.343g/cm³
• LogP: 1.62770
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 153.053826475
• Heavy Atom Count: 11
• Complexity: 145

Purity/Quality:

97% ^*data from raw suppliers

N-Methyl-2-nitropyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1=C(N=CC=C1)[N+](=O)[O-]

Technology Process of 3-Pyridinamine, N-methyl-2-nitro-

There total 11 articles about 3-Pyridinamine, N-methyl-2-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-fuoro-2-nitropyridine (54231-35-5) + methylamine (74-89-5) → 3-(N-methylamino)-2-nitropyridine (32605-06-4)

Guidance literature:

In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.5012/jkcs.2013.57.3.361

Reference yield: 59.0%

3-methoxy-2-nitropyridine (20265-37-6) + methylamine (74-89-5) → 3-(N-methylamino)-2-nitropyridine (32605-06-4)

Guidance literature:

In ethanol; Reflux;

DOI:10.1515/hc-2013-0059

Reference yield:

3-amino-2-nitropyridine (13269-19-7) → 3-(N-methylamino)-2-nitropyridine (32605-06-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrafluoroboric acid / toluene / 120 °C / Inert atmosphere

2: tetrahydrofuran / 20 °C / Inert atmosphere

With tetrafluoroboric acid; In tetrahydrofuran; toluene;

DOI:10.5012/jkcs.2013.57.3.361

upstream raw materials:

N-methyl-N-(3-pyridyl)nitramine

methyl-(2-nitro-[3]pyridyl)-carbamic acid ethyl ester

sulfuric acid

3-methoxy-2-nitropyridine

Downstream raw materials:

2-amino-3-methylaminopyridine

2-amino-1-methylimidazo[4,5-b]pyridine

2-benzyl-1-methyl-1H-imidazo[4,5-b]pyridine