5-[7-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-1-[(4-methylphenyl)thio]heptyl]-2-methoxyphenol

Base Information

Chemical Name:5-[7-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-1-[(4-methylphenyl)thio]heptyl]-2-methoxyphenol
CAS No.:167159-50-4
Molecular Formula:C₃₂H₄₁NO₄S
Molecular Weight:535.748
Hs Code.:

Synonyms:5-[7-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-1-[(4-methylphenyl)thio]heptyl]-2-methoxyphenol

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Chemical Property of 5-[7-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-1-[(4-methylphenyl)thio]heptyl]-2-methoxyphenol

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Technology Process of 5-[7-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-1-[(4-methylphenyl)thio]heptyl]-2-methoxyphenol

There total 7 articles about 5-[7-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-1-[(4-methylphenyl)thio]heptyl]-2-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

: 167159-20-8
2-{7-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-7-p-tolylsulfanyl-heptyl}-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline

: 167159-50-4
5-[7-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-1-[(4-methylphenyl)thio]heptyl]-2-methoxyphenol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 15h;
DOI:10.1021/jm9804477

Reference yield:

: 4383-06-6
3-hydroxy-4-methoxybenzyl alcohol

: 167159-50-4
5-[7-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-1-[(4-methylphenyl)thio]heptyl]-2-methoxyphenol

Guidance literature:: Multi-step reaction with 6 steps

1: HBr(g) / toluene / 0.5 h / 0 °C

2: aq. KOH, (Bu)4NHSO₄ / toluene / 12 h / 25 °C

3: 94 percent / 4-(dimethylamino)pyridine / pyridine / Heating

4: 1.) N-BuLi, phenanthroline / 1.) THF, hexane, from -78 deg C to O deg C, 2.) THF, hexane, from -78 deg C to 25 deg C

5: 82 percent / diisopropylethylamine, NaI / acetonitrile / Heating

6: 99.5 percent / tetrabutylammonium fluoride / tetrahydrofuran / 15 h / 25 °C

With dmap; potassium hydroxide; n-butyllithium; Phenanthroline; tetrabutyl ammonium fluoride; hydrogen bromide; tetra(n-butyl)ammonium hydrogensulfate; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; pyridine; toluene; acetonitrile;
DOI:10.1021/jm9804477

Reference yield:

: 111394-51-5
3-hydroxy-4-methoxybenzyl bromide

: 167159-50-4
5-[7-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-1-[(4-methylphenyl)thio]heptyl]-2-methoxyphenol

Guidance literature:: Multi-step reaction with 5 steps

1: aq. KOH, (Bu)4NHSO₄ / toluene / 12 h / 25 °C

2: 94 percent / 4-(dimethylamino)pyridine / pyridine / Heating

3: 1.) N-BuLi, phenanthroline / 1.) THF, hexane, from -78 deg C to O deg C, 2.) THF, hexane, from -78 deg C to 25 deg C

4: 82 percent / diisopropylethylamine, NaI / acetonitrile / Heating

5: 99.5 percent / tetrabutylammonium fluoride / tetrahydrofuran / 15 h / 25 °C

With dmap; potassium hydroxide; n-butyllithium; Phenanthroline; tetrabutyl ammonium fluoride; tetra(n-butyl)ammonium hydrogensulfate; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; pyridine; toluene; acetonitrile;
DOI:10.1021/jm9804477