2-[7-[3-(2-Chloroethoxy)-4-methoxyphenyl]-7-[(4-methyl phenyl)thio]heptyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-isoquinoline

Base Information

Chemical Name:2-[7-[3-(2-Chloroethoxy)-4-methoxyphenyl]-7-[(4-methyl phenyl)thio]heptyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-isoquinoline
CAS No.:167159-21-9
Molecular Formula:C₃₄H₄₄ClNO₄S
Molecular Weight:598.247
Hs Code.:

Synonyms:2-[7-[3-(2-Chloroethoxy)-4-methoxyphenyl]-7-[(4-methyl phenyl)thio]heptyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-isoquinoline

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Chemical Property of 2-[7-[3-(2-Chloroethoxy)-4-methoxyphenyl]-7-[(4-methyl phenyl)thio]heptyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-isoquinoline

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Technology Process of 2-[7-[3-(2-Chloroethoxy)-4-methoxyphenyl]-7-[(4-methyl phenyl)thio]heptyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-isoquinoline

There total 8 articles about 2-[7-[3-(2-Chloroethoxy)-4-methoxyphenyl]-7-[(4-methyl phenyl)thio]heptyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 80-41-1
2-chloroethyl tosylate

: 167159-50-4
5-[7-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-1-[(4-methylphenyl)thio]heptyl]-2-methoxyphenol

: 167159-21-9
2-[7-[3-(2-Chloroethoxy)-4-methoxyphenyl]-7-[(4-methyl phenyl)thio]heptyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-isoquinoline

Guidance literature:: With sodium hydride; In butanone; for 48h; Heating;
DOI:10.1021/jm9804477

Reference yield:

: 67-56-1
methanol

: 80-41-1
2-chloroethyl tosylate

: 167159-50-4
5-[7-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-1-[(4-methylphenyl)thio]heptyl]-2-methoxyphenol

: 167159-21-9
2-[7-[3-(2-Chloroethoxy)-4-methoxyphenyl]-7-[(4-methyl phenyl)thio]heptyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-isoquinoline

Guidance literature:: In diethyl ether; hexane; butanone;

Reference yield:

: 4383-06-6
3-hydroxy-4-methoxybenzyl alcohol

: 167159-21-9
2-[7-[3-(2-Chloroethoxy)-4-methoxyphenyl]-7-[(4-methyl phenyl)thio]heptyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-isoquinoline

Guidance literature:: Multi-step reaction with 7 steps

1: HBr(g) / toluene / 0.5 h / 0 °C

2: aq. KOH, (Bu)4NHSO₄ / toluene / 12 h / 25 °C

3: 94 percent / 4-(dimethylamino)pyridine / pyridine / Heating

4: 1.) N-BuLi, phenanthroline / 1.) THF, hexane, from -78 deg C to O deg C, 2.) THF, hexane, from -78 deg C to 25 deg C

5: 82 percent / diisopropylethylamine, NaI / acetonitrile / Heating

6: 99.5 percent / tetrabutylammonium fluoride / tetrahydrofuran / 15 h / 25 °C

7: 27 percent / NaH / butan-2-one / 48 h / Heating

With dmap; potassium hydroxide; n-butyllithium; Phenanthroline; tetrabutyl ammonium fluoride; hydrogen bromide; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; pyridine; toluene; acetonitrile; butanone;
DOI:10.1021/jm9804477