methyl 2-{4-[(tert-butoxycarbonyl)amino]-1H-indol-1-yl}-2-(4-chlorophenyl)butanoate

Base Information

Chemical Name:methyl 2-{4-[(tert-butoxycarbonyl)amino]-1H-indol-1-yl}-2-(4-chlorophenyl)butanoate
CAS No.:1389326-22-0
Molecular Formula:C₂₄H₂₇ClN₂O₄
Molecular Weight:442.942
Hs Code.:

Synonyms:methyl 2-{4-[(tert-butoxycarbonyl)amino]-1H-indol-1-yl}-2-(4-chlorophenyl)butanoate

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Chemical Property of methyl 2-{4-[(tert-butoxycarbonyl)amino]-1H-indol-1-yl}-2-(4-chlorophenyl)butanoate

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Technology Process of methyl 2-{4-[(tert-butoxycarbonyl)amino]-1H-indol-1-yl}-2-(4-chlorophenyl)butanoate

There total 6 articles about methyl 2-{4-[(tert-butoxycarbonyl)amino]-1H-indol-1-yl}-2-(4-chlorophenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1389326-21-9
methyl {4-[(tert-butoxycarbonyl)amino]-1H-indol-1-yl}(4-chlorophenyl)acetate

: 75-03-6
ethyl iodide

: 1389326-22-0
methyl 2-{4-[(tert-butoxycarbonyl)amino]-1H-indol-1-yl}-2-(4-chlorophenyl)butanoate

Guidance literature:: methyl {4-[(tert-butoxycarbonyl)amino]-1H-indol-1-yl}(4-chlorophenyl)acetate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.25h;

ethyl iodide; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 2h;

Reference yield:

: 24091-92-7
methyl 2-bromo-2-(4-chlorophenyl)acetate

: 1389326-22-0
methyl 2-{4-[(tert-butoxycarbonyl)amino]-1H-indol-1-yl}-2-(4-chlorophenyl)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

1.2: 3 h / 0 °C

2.1: hydrogen / 10% Pt/activated carbon / ethyl acetate / 3 h / Inert atmosphere

3.1: sodium hydrogencarbonate / 1,4-dioxane; water

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

4.2: 2 h / 0 °C

With hydrogen; sodium hydride; sodium hydrogencarbonate; 10% Pt/activated carbon; In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1389323-98-1
methyl (4-chlorophenyl)(4-nitro-1H-indol-1-yl)acetate

: 1389326-22-0
methyl 2-{4-[(tert-butoxycarbonyl)amino]-1H-indol-1-yl}-2-(4-chlorophenyl)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / 10% Pt/activated carbon / ethyl acetate / 3 h / Inert atmosphere

2.1: sodium hydrogencarbonate / 1,4-dioxane; water

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

3.2: 2 h / 0 °C

With hydrogen; sodium hydride; sodium hydrogencarbonate; 10% Pt/activated carbon; In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;