N-(5-(1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)-4-chlorobenzamide

Base Information

Chemical Name:N-(5-(1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)-4-chlorobenzamide
CAS No.:1419599-83-9
Molecular Formula:C₂₉H₂₉Cl₂N₅O₂
Molecular Weight:550.488
Hs Code.:

Synonyms:N-(5-(1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)-4-chlorobenzamide

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Chemical Property of N-(5-(1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)-4-chlorobenzamide

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Technology Process of N-(5-(1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)-4-chlorobenzamide

There total 4 articles about N-(5-(1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)-4-chlorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1254713-63-7
(3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methanamine

: 1419603-71-6
2-(6-(4-chlorobenzamido)pyridin-3-yl)propanoic acid

: 1419599-83-9
N-(5-(1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)-4-chlorobenzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 23 ℃;

Reference yield:

: 197376-47-9
ethyl (6-chloro-pyridin-3-yl)acetate

: 1419599-83-9
N-(5-(1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)-4-chlorobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

2: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / Reflux; Inert atmosphere

3: lithium hydroxide monohydrate; water / tetrahydrofuran / 2 h / 40 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 23 °C

With lithium hydroxide monohydrate; water; palladium diacetate; sodium hydride; benzotriazol-1-ol; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

Reference yield:

: 39891-13-9
2-(6-chloropyridin-3-yl)acetic acid

: 1419599-83-9
N-(5-(1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)-4-chlorobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / 4 h / Reflux

2: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

3: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / Reflux; Inert atmosphere

4: lithium hydroxide monohydrate; water / tetrahydrofuran / 2 h / 40 °C

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 23 °C

With lithium hydroxide monohydrate; sulfuric acid; water; palladium diacetate; sodium hydride; benzotriazol-1-ol; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;