(R)-α-<<(1,1-dimethylethyl)amino>methyl>-α-<(1,1-dimethylethyl)dimethylsilyloxy>-4-methoxybenzenemethane

Base Information

Chemical Name:(R)-α-<<(1,1-dimethylethyl)amino>methyl>-α-<(1,1-dimethylethyl)dimethylsilyloxy>-4-methoxybenzenemethane
CAS No.:160518-87-6
Molecular Formula:C₁₉H₃₅NO₂Si
Molecular Weight:337.578
Hs Code.:

Synonyms:(R)-α-<<(1,1-dimethylethyl)amino>methyl>-α-<(1,1-dimethylethyl)dimethylsilyloxy>-4-methoxybenzenemethane

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Chemical Property of (R)-α-<<(1,1-dimethylethyl)amino>methyl>-α-<(1,1-dimethylethyl)dimethylsilyloxy>-4-methoxybenzenemethane

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Technology Process of (R)-α-<<(1,1-dimethylethyl)amino>methyl>-α-<(1,1-dimethylethyl)dimethylsilyloxy>-4-methoxybenzenemethane

There total 3 articles about (R)-α-<<(1,1-dimethylethyl)amino>methyl>-α-<(1,1-dimethylethyl)dimethylsilyloxy>-4-methoxybenzenemethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 97070-73-0
(R)-(+)-α-Hydroxy-4-methoxybenzeneacetonitrile

: 160518-87-6
(R)-α-<<(1,1-dimethylethyl)amino>methyl>-α-<(1,1-dimethylethyl)dimethylsilyloxy>-4-methoxybenzenemethane

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

2: 1.) 1M DIBAL; NH₄Br, 3.) NaBH₄ / 1.) toluene, ether, -70 deg C, 3 h; MeOH, -60 to -70 deg C, 10 min, 2.) toluene, MeOH, -70 deg C to room temp., 75 min, 3.) toluene, MeOH, 0 deg C to room temp., overnight

With 1H-imidazole; sodium tetrahydroborate; diisobutylaluminium hydride; ammonium bromide; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)85686-6

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 160518-87-6
(R)-α-<<(1,1-dimethylethyl)amino>methyl>-α-<(1,1-dimethylethyl)dimethylsilyloxy>-4-methoxybenzenemethane

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / (S,S)-cyclo(phenylalanylhistidyl) / toluene / 36 h / -15 °C

2: 86 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

3: 1.) 1M DIBAL; NH₄Br, 3.) NaBH₄ / 1.) toluene, ether, -70 deg C, 3 h; MeOH, -60 to -70 deg C, 10 min, 2.) toluene, MeOH, -70 deg C to room temp., 75 min, 3.) toluene, MeOH, 0 deg C to room temp., overnight

With 1H-imidazole; sodium tetrahydroborate; (S,S)-cyclo(phenylalanylhistidyl); diisobutylaluminium hydride; ammonium bromide; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)85686-6

Reference yield:

: 120390-76-3
(R)-(+)-α-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzeneacetonitrile

: 75-64-9
tert-butylamine

: 160518-87-6
(R)-α-<<(1,1-dimethylethyl)amino>methyl>-α-<(1,1-dimethylethyl)dimethylsilyloxy>-4-methoxybenzenemethane

Guidance literature:: With sodium tetrahydroborate; diisobutylaluminium hydride; ammonium bromide; Yield given. Multistep reaction; 1.) toluene, ether, -70 deg C, 3 h; MeOH, -60 to -70 deg C, 10 min, 2.) toluene, MeOH, -70 deg C to room temp., 75 min, 3.) toluene, MeOH, 0 deg C to room temp., overnight;
DOI:10.1016/S0040-4020(01)85686-6