1-(4-fluorophenyl)-2-(4-(2-hydroxy-2-(4-(phenylsulfonyl)phenyl)propyl)-1H-1,2,3-triazol-1-yl)ethanone

Base Information

Chemical Name:1-(4-fluorophenyl)-2-(4-(2-hydroxy-2-(4-(phenylsulfonyl)phenyl)propyl)-1H-1,2,3-triazol-1-yl)ethanone
CAS No.:1621085-18-4
Molecular Formula:C₂₅H₂₂FN₃O₄S
Molecular Weight:479.532
Hs Code.:

Synonyms:1-(4-fluorophenyl)-2-(4-(2-hydroxy-2-(4-(phenylsulfonyl)phenyl)propyl)-1H-1,2,3-triazol-1-yl)ethanone

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Chemical Property of 1-(4-fluorophenyl)-2-(4-(2-hydroxy-2-(4-(phenylsulfonyl)phenyl)propyl)-1H-1,2,3-triazol-1-yl)ethanone

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Technology Process of 1-(4-fluorophenyl)-2-(4-(2-hydroxy-2-(4-(phenylsulfonyl)phenyl)propyl)-1H-1,2,3-triazol-1-yl)ethanone

There total 2 articles about 1-(4-fluorophenyl)-2-(4-(2-hydroxy-2-(4-(phenylsulfonyl)phenyl)propyl)-1H-1,2,3-triazol-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1621085-04-8
2-(4-(phenylsulfonyl)phenyl)pent-4-yn-2-ol

: 403-29-2
2-bromo-4'-fluoroacetophenone

: 1621085-18-4
1-(4-fluorophenyl)-2-(4-(2-hydroxy-2-(4-(phenylsulfonyl)phenyl)propyl)-1H-1,2,3-triazol-1-yl)ethanone

Guidance literature:: With sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 25 - 30 ℃; for 0.5h; Sonication; Green chemistry;
DOI:10.1016/j.ejmech.2014.07.042

Reference yield:

: 65085-83-8
4'-(phenylsulfonyl)acetophenone

: 1621085-18-4
1-(4-fluorophenyl)-2-(4-(2-hydroxy-2-(4-(phenylsulfonyl)phenyl)propyl)-1H-1,2,3-triazol-1-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: zinc; zinc dibromide / tetrahydrofuran / 1.5 h / 25 - 30 °C / Sonication

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate; sodium azide / water; tert-butyl alcohol / 0.5 h / 25 - 30 °C / Sonication; Green chemistry

With sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; zinc dibromide; zinc; In tetrahydrofuran; water; tert-butyl alcohol; 1: |Barbier Coupling Reaction;
DOI:10.1016/j.ejmech.2014.07.042