methyl (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methylpropionate

Base Information

Chemical Name:methyl (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methylpropionate
CAS No.:911411-83-1
Molecular Formula:C₁₃H₁₆F₃NO₃
Molecular Weight:291.27
Hs Code.:

Synonyms:methyl (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methylpropionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methylpropionate

Chemical Property:

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Technology Process of methyl (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methylpropionate

There total 4 articles about methyl (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 911411-54-6
(2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methylpropionitrile

: 67-56-1
methanol

: 911411-83-1
methyl (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methylpropionate

Guidance literature:: With hydrogenchloride; for 6h; Heating;
DOI:10.1021/jo0607717

Reference yield:

: (-)-(4R)-2-(trifluoromethyl)-2-methyl-4-phenyl-1,3-oxazolidine

: 911411-83-1
methyl (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methylpropionate

Guidance literature:: Multi-step reaction with 3 steps

1: LDA / tetrahydrofuran / -78 °C

2: Yb(OTf)3 / CH₂Cl₂ / 0 - 20 °C

3: 80 percent / HCl (gas) / 6 h / Heating

With hydrogenchloride; ytterbium(III) triflate; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0607717

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 911411-83-1
methyl (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methylpropionate

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / pyridinium p-toluenesulfonate / toluene / 12 h / Heating

2: LDA / tetrahydrofuran / -78 °C

3: Yb(OTf)3 / CH₂Cl₂ / 0 - 20 °C

4: 80 percent / HCl (gas) / 6 h / Heating

With hydrogenchloride; pyridinium p-toluenesulfonate; ytterbium(III) triflate; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jo0607717