1,7,8-triaza-3,3,6,6-tetramethyl-5-oxa-2-oxo-1-phenylspiro<3,4>oct-7-ene

Base Information

• Chemical Name: 1,7,8-triaza-3,3,6,6-tetramethyl-5-oxa-2-oxo-1-phenylspiro<3,4>oct-7-ene
• CAS No.: 134209-90-8
• Molecular Formula: C₁₄H₁₇N₃O₂
• Molecular Weight: 259.308
• Mol file: 134209-90-8.mol

Synonyms:1,7,8-triaza-3,3,6,6-tetramethyl-5-oxa-2-oxo-1-phenylspiro<3,4>oct-7-ene

Chemical Property of 1,7,8-triaza-3,3,6,6-tetramethyl-5-oxa-2-oxo-1-phenylspiro<3,4>oct-7-ene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,7,8-triaza-3,3,6,6-tetramethyl-5-oxa-2-oxo-1-phenylspiro<3,4>oct-7-ene

There total 4 articles about 1,7,8-triaza-3,3,6,6-tetramethyl-5-oxa-2-oxo-1-phenylspiro<3,4>oct-7-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

5,5-dimethyl-2-phenylimino-Δ3-1,3,4-oxadiazoline (77637-40-2) + isobutyryl chloride (79-30-1) → 1,7,8-triaza-3,3,6,6-tetramethyl-5-oxa-2-oxo-1-phenylspiro<3,4>oct-7-ene (134209-90-8)

Guidance literature:

With triethylamine; In dichloromethane; at 30 ℃; Inert atmosphere; Cooling with ice;

DOI:10.1021/jo201273p

Reference yield: 60.0%

isobutyryl chloride (79-30-1) + 2-phenylimino-5,5-dimethyl-Δ3-1,3,4-oxadiazoline (21449-52-5) → 1,7,8-triaza-3,3,6,6-tetramethyl-5-oxa-2-oxo-1-phenylspiro<3,4>oct-7-ene (134209-90-8)

Guidance literature:

With triethylamine; In dichloromethane; Ambient temperature;

Reference yield:

acetone 4-phenylsemicarbazone (78002-37-6) → 1,7,8-triaza-3,3,6,6-tetramethyl-5-oxa-2-oxo-1-phenylspiro<3,4>oct-7-ene (134209-90-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Pb(OAc)4, K₂CO₃ / CH₂Cl₂

2: 60 percent / Et₃N / CH₂Cl₂ / Ambient temperature

With lead(IV) acetate; potassium carbonate; triethylamine; In dichloromethane;

upstream raw materials:

5,5-dimethyl-2-phenylimino-Δ³-1,3,4-oxadiazoline

[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-[5,5-dimethyl-5H-[1,3,4]oxadiazol-(2Z)-ylidene]-amine

isobutyryl chloride

2-phenylimino-5,5-dimethyl-Δ³-1,3,4-oxadiazoline

Downstream raw materials:

(RS,SR)-1'-(3'',3''-dimethyl-1''-phenylazetidin-2''-one)-3,3,5'-trimethyl-1-phenylspiro[azetidine-4,3'-indoline]-2,2'-dione

(RS,RS)-1'-(3'',3''-dimethyl-1''-phenylazetidin-2''-one)-3,3,5'-trimethyl-1-phenylspiro[azetidine-4,3'-indoline]-2,2'-dione

3,3-dimethyl-1,8-diphenyl-3,3a-dihydroindeno[2,1-b]pyrrol-2-one

3,3-dimethyl-1,8-diphenyl-3,8-dihydroindeno[2,1-b]pyrrol-2-one