1-(2-chlorophenyl)-3-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)thiourea

Base Information

Chemical Name:1-(2-chlorophenyl)-3-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)thiourea
CAS No.:1418149-89-9
Molecular Formula:C₂₇H₂₄ClN₉OS₂
Molecular Weight:590.132
Hs Code.:

Synonyms:1-(2-chlorophenyl)-3-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)thiourea

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Chemical Property of 1-(2-chlorophenyl)-3-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)thiourea

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Technology Process of 1-(2-chlorophenyl)-3-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)thiourea

There total 11 articles about 1-(2-chlorophenyl)-3-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.9%

: 2740-81-0
2-chlorophenylisothiocyanate

: 1418149-58-2
7-(4-methylpiperazin-1-yl)-4-[(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-yl)sulfanyl]quinazolin-6-amine

: 1418149-89-9
1-(2-chlorophenyl)-3-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)thiourea

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1007/s00044-012-0408-0

Reference yield:

: 53449-14-2
7-chloro-6-nitro-4(3H)-quinazolinone

: 1418149-89-9
1-(2-chlorophenyl)-3-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)thiourea

Guidance literature:: Multi-step reaction with 5 steps

1.1: phosphorus pentachloride / 3 h / 160 °C

2.1: potassium carbonate / isopropyl alcohol / 7 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / Reflux

3.2: 5 h / Reflux

4.1: acetic acid; iron / water / 5 h / 10 - 20 °C

5.1: N,N-dimethyl-formamide / 12 h / 20 °C

With phosphorus pentachloride; iron; potassium carbonate; acetic acid; In water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1007/s00044-012-0408-0

Reference yield:

: 59-67-6
nicotinic acid

: 1418149-89-9
1-(2-chlorophenyl)-3-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)thiourea

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / 4 h / 20 °C / Reflux

2.1: hydrazine hydrate / ethanol / Reflux

3.1: potassium hydroxide / ethanol / 5 h / Reflux

4.1: potassium carbonate / isopropyl alcohol / 7 h / Reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / Reflux

5.2: 5 h / Reflux

6.1: acetic acid; iron / water / 5 h / 10 - 20 °C

7.1: N,N-dimethyl-formamide / 12 h / 20 °C

With potassium hydroxide; sulfuric acid; iron; potassium carbonate; hydrazine hydrate; acetic acid; In ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1007/s00044-012-0408-0