3-<<(tert-Butyldimethylsilyl)oxy>methyl>-1-methoxy-5-methyl-1,4-cyclohexadiene

Base Information

• Chemical Name: 3-<<(tert-Butyldimethylsilyl)oxy>methyl>-1-methoxy-5-methyl-1,4-cyclohexadiene
• CAS No.: 124908-72-1
• Molecular Formula: C₁₅H₂₈O₂Si
• Molecular Weight: 268.472

Synonyms:3-<<(tert-Butyldimethylsilyl)oxy>methyl>-1-methoxy-5-methyl-1,4-cyclohexadiene

Chemical Property of 3-<<(tert-Butyldimethylsilyl)oxy>methyl>-1-methoxy-5-methyl-1,4-cyclohexadiene

Chemical Property:

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Technology Process of 3-<<(tert-Butyldimethylsilyl)oxy>methyl>-1-methoxy-5-methyl-1,4-cyclohexadiene

There total 3 articles about 3-<<(tert-Butyldimethylsilyl)oxy>methyl>-1-methoxy-5-methyl-1,4-cyclohexadiene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Methoxy-5-methyl-cyclohexa-2,5-dienecarboxylic acid (124908-71-0) → 3-<<(tert-Butyldimethylsilyl)oxy>methyl>-1-methoxy-5-methyl-1,4-cyclohexadiene (124908-72-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / diethyl ether

2: 91 percent / i-Bu₂AlH

3: 84 percent / imidazole / CH₂Cl₂ / 0.25 h / Ambient temperature

With 1H-imidazole; diisobutylaluminium hydride; In diethyl ether; dichloromethane;

DOI:10.1039/c39890000712

Reference yield:

3-Methoxy-5-methyl-cyclohexa-2,5-dienecarboxylic acid methyl ester → 3-<<(tert-Butyldimethylsilyl)oxy>methyl>-1-methoxy-5-methyl-1,4-cyclohexadiene (124908-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / i-Bu₂AlH

2: 84 percent / imidazole / CH₂Cl₂ / 0.25 h / Ambient temperature

With 1H-imidazole; diisobutylaluminium hydride; In dichloromethane;

DOI:10.1039/c39890000712

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) + (3-Methoxy-5-methyl-cyclohexa-2,5-dienyl)-methanol (142459-32-3) → 3-<<(tert-Butyldimethylsilyl)oxy>methyl>-1-methoxy-5-methyl-1,4-cyclohexadiene (124908-72-1)

Guidance literature:

With 1H-imidazole; In dichloromethane; for 0.25h;

DOI:10.1021/jo00036a026

upstream raw materials:

tert-butyldimethylsilyl chloride

(3-Methoxy-5-methyl-cyclohexa-2,5-dienyl)-methanol

3-Methoxy-5-methyl-cyclohexa-2,5-dienecarboxylic acid

Downstream raw materials:

(Z)-3-[(1R,2R,3S)-2-((R)-Cyano-methyl-methyl)-3-methyl-cyclohexyl]-2-((2S,3S,6R)-6-{(E)-3-[(2S,5S)-5-((R)-1-methoxy-ethyl)-tetrahydro-furan-2-yl]-propenyl}-3-methyl-tetrahydro-pyran-2-yl)-acrylic acid methyl ester

(E)-3-[(1R,2R,3S)-2-((R)-Cyano-methyl-methyl)-3-methyl-cyclohexyl]-2-((2S,3S,6R)-6-{(E)-3-[(2S,5S)-5-((R)-1-methoxy-ethyl)-tetrahydro-furan-2-yl]-propenyl}-3-methyl-tetrahydro-pyran-2-yl)-acrylic acid methyl ester

C₄₁H₆₈O₈Si

4-Methoxy-3-((R)-2-{(1R,2R,6S)-2-[(E)-2-((2S,3S,6R)-6-{(E)-3-[(2S,5S)-5-((R)-1-methoxy-ethyl)-tetrahydro-furan-2-yl]-propenyl}-3-methyl-tetrahydro-pyran-2-yl)-3-triethylsilanyloxy-propenyl]-6-methyl-cyclohexyl}-propionyl)-5-methylene-5H-furan-2-one

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