(R)-N-Methoxy-2-[2-methoxy-4-((2S,3R,4R,5S)-5-{3-methoxy-4-[(R)-1-(methoxy-methyl-carbamoyl)-ethoxy]-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-phenoxy]-N-methyl-propionamide

Base Information

Chemical Name:(R)-N-Methoxy-2-[2-methoxy-4-((2S,3R,4R,5S)-5-{3-methoxy-4-[(R)-1-(methoxy-methyl-carbamoyl)-ethoxy]-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-phenoxy]-N-methyl-propionamide
CAS No.:915158-79-1
Molecular Formula:C₃₀H₄₂N₂O₉
Molecular Weight:574.671
Hs Code.:

(R)-N-Methoxy-2-[2-methoxy-4-((2S,3R,4R,5S)-5-{3-methoxy-4-[(R)-1-(methoxy-methyl-carbamoyl)-ethoxy]-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-phenoxy]-N-methyl-propionamide

Synonyms:(R)-N-Methoxy-2-[2-methoxy-4-((2S,3R,4R,5S)-5-{3-methoxy-4-[(R)-1-(methoxy-methyl-carbamoyl)-ethoxy]-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-phenoxy]-N-methyl-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-Methoxy-2-[2-methoxy-4-((2S,3R,4R,5S)-5-{3-methoxy-4-[(R)-1-(methoxy-methyl-carbamoyl)-ethoxy]-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-phenoxy]-N-methyl-propionamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-N-Methoxy-2-[2-methoxy-4-((2S,3R,4R,5S)-5-{3-methoxy-4-[(R)-1-(methoxy-methyl-carbamoyl)-ethoxy]-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-phenoxy]-N-methyl-propionamide

There total 6 articles about (R)-N-Methoxy-2-[2-methoxy-4-((2S,3R,4R,5S)-5-{3-methoxy-4-[(R)-1-(methoxy-methyl-carbamoyl)-ethoxy]-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-phenoxy]-N-methyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 915158-68-8
(R)-2-(2-Methoxy-4-{(2S,3R,4R,5S)-5-[3-methoxy-4-((R)-1-methoxycarbonyl-ethoxy)-phenyl]-3,4-dimethyl-tetrahydro-furan-2-yl}-phenoxy)-propionic acid methyl ester

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 915158-79-1
(R)-N-Methoxy-2-[2-methoxy-4-((2S,3R,4R,5S)-5-{3-methoxy-4-[(R)-1-(methoxy-methyl-carbamoyl)-ethoxy]-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-phenoxy]-N-methyl-propionamide

Guidance literature:: With dimethylaluminum chloride; In hexane; dichloromethane; at 0 - 20 ℃;
DOI:10.1021/ol0621710

Reference yield:

: 915158-67-7
4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenol

: 915158-79-1
(R)-N-Methoxy-2-[2-methoxy-4-((2S,3R,4R,5S)-5-{3-methoxy-4-[(R)-1-(methoxy-methyl-carbamoyl)-ethoxy]-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-phenoxy]-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / H₂ / Pd(OH)2/C / ethyl acetate / 0.33 h / 20 °C

2: 95 percent / BEMP / CH₂Cl₂ / -40 - 0 °C

3: 72 percent / Me₂AlCl / CH₂Cl₂; hexane / 0 - 20 °C

With hydrogen; dimethylaluminum chloride; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; palladium dihydroxide; In hexane; dichloromethane; ethyl acetate;
DOI:10.1021/ol0621710

Reference yield:

: 915158-64-4
(1R,2R,3R,4S)-4-[4-(4-benzyloxy-3-methoxyphenyl)-1-hydroxy-4-methoxymethoxy-2,3-dimethylbutyl]-2-methoxyphenol

: 915158-79-1
(R)-N-Methoxy-2-[2-methoxy-4-((2S,3R,4R,5S)-5-{3-methoxy-4-[(R)-1-(methoxy-methyl-carbamoyl)-ethoxy]-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-phenoxy]-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 94 percent / Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

2.1: MsCl; Et₃N / CH₂Cl₂ / -78 - 0 °C

2.2: 232 mg / LiOH; H₂O / tetrahydrofuran; methanol / 2 h / 20 °C

3.1: 94 percent / H₂ / Pd(OH)2/C / ethyl acetate / 0.33 h / 20 °C

4.1: 95 percent / BEMP / CH₂Cl₂ / -40 - 0 °C

5.1: 72 percent / Me₂AlCl / CH₂Cl₂; hexane / 0 - 20 °C

With hydrogen; dimethylaluminum chloride; methanesulfonyl chloride; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; triethylamine; palladium dihydroxide; In hexane; dichloromethane; ethyl acetate;
DOI:10.1021/ol0621710