FMOC-D-2-AMINOADIPIC ACID

Base Information

• Chemical Name: FMOC-D-2-AMINOADIPIC ACID
• CAS No.: 218457-73-9
• Molecular Formula: C₂₁H₂₁NO₆
• Molecular Weight: 383.401
• Hs Code.: 2922499990
• Mol file: 218457-73-9.mol

Synonyms:FMOC-D-2-AMINOADIPIC ACID;FMOC-D-HOMOGLUTAMIC ACID;FMOC-D-AAD-OH;FMOC-D-ALPHA-AMINOADIPIC ACID;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-ALPHA-D-AMINOADIPIC ACID

Chemical Property of FMOC-D-2-AMINOADIPIC ACID

Chemical Property:

• PSA: 112.93000
• LogP: 3.62410
• Storage Temp.: Store at 0°C

Purity/Quality:

98%Min ^*data from raw suppliers

Fmoc-D-2-aminoadipicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-D-2-AMINOADIPIC ACID

There total 3 articles about FMOC-D-2-AMINOADIPIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

L-homoglutamic acid (1118-90-7) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → Fmoc-L-α-aminoadipic acid (218457-73-9,250384-77-1)

Guidance literature:

With sodium hydrogencarbonate; In water; acetone;

Reference yield: 94.0%

formic acid (64-18-6) + (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)pent-4-enoic acid (170642-28-1) → (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)adipic acid (218457-73-9,250384-77-1)

Guidance literature:

With palladium diacetate; acetic anhydride; P(p-C₆H₄F)3; In toluene; at 80 ℃; for 48h; Inert atmosphere; Sealed tube;

Reference yield:

formic acid (64-18-6) + 2-(9H-fluoren-9-ylmethoxycarbonylamino)-pent-4-enoic acid (146549-21-5) → Fmoc-L-α-aminoadipic acid (218457-73-9,250384-77-1)

Guidance literature:

With palladium diacetate; acetic anhydride; P(p-C₆H₄F)3; In toluene; at 80 ℃; for 48h; regioselective reaction; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.9b02101

upstream raw materials:

formic acid

2-(9H-fluoren-9-ylmethoxycarbonylamino)-pent-4-enoic acid

L-homoglutamic acid

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Refernces

• 1、 Ren, Wenlong,Chu, Jianxiao,Sun, Fei,Shi, Yian. "Pd-Catalyzed Highly Chemo- And Regioselective Hydrocarboxylation of Terminal Alkyl Olefins with Formic Acid". supporting information. p. 5967 - 5970. Retrieved 2019/08/26.