(1-benzyl-1H-indol-3-yl)-(4,6-dimethoxy-2-methyl-pyridin-3-yl)-methanone

Base Information

Chemical Name:(1-benzyl-1H-indol-3-yl)-(4,6-dimethoxy-2-methyl-pyridin-3-yl)-methanone
CAS No.:797050-69-2
Molecular Formula:C₂₄H₂₂N₂O₃
Molecular Weight:386.45
Hs Code.:

(1-benzyl-1<i>H</i>-indol-3-yl)-(4,6-dimethoxy-2-methyl-pyridin-3-yl)-methanone

Synonyms:(1-benzyl-1H-indol-3-yl)-(4,6-dimethoxy-2-methyl-pyridin-3-yl)-methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1-benzyl-1H-indol-3-yl)-(4,6-dimethoxy-2-methyl-pyridin-3-yl)-methanone

Chemical Property:

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Technology Process of (1-benzyl-1H-indol-3-yl)-(4,6-dimethoxy-2-methyl-pyridin-3-yl)-methanone

There total 5 articles about (1-benzyl-1H-indol-3-yl)-(4,6-dimethoxy-2-methyl-pyridin-3-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 75-16-1
methylmagnesium bromide

: 797050-68-1
1-benzyl-3-(4,6-dimethoxy-2-trifluoromethanesulfonyloxynicotinoyl)indole

: 797050-69-2
(1-benzyl-1H-indol-3-yl)-(4,6-dimethoxy-2-methyl-pyridin-3-yl)-methanone

Guidance literature:: Ni(DPPE)2Cl₂;
DOI:10.1055/s-2004-831317

Reference yield:

: 91591-88-7
2,4,6-trimethoxypyridine

: 797050-69-2
(1-benzyl-1H-indol-3-yl)-(4,6-dimethoxy-2-methyl-pyridin-3-yl)-methanone

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / TiCl₄ / CH₂Cl₂ / 18 h / 20 °C

2: 94 percent / 2CuO*Cr₂O₃ / quinoline / 180 °C

3: 94 percent / HBr; AcOH / 50 °C

4: 94 percent / Et₃N / CH₂Cl₂

5: 79 percent / NiCl₂(dppe)2

With chromium(III) oxide; hydrogen bromide; titanium tetrachloride; acetic acid; triethylamine; copper(II) oxide; Ni(DPPE)2Cl₂; In quinoline; dichloromethane; 1: Friedel-Crafts reaction;
DOI:10.1055/s-2004-831317

Reference yield:

: 151054-77-2
1-benzylindole-2,3-dicarboxylic anhydride

: 797050-69-2
(1-benzyl-1H-indol-3-yl)-(4,6-dimethoxy-2-methyl-pyridin-3-yl)-methanone

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / TiCl₄ / CH₂Cl₂ / 18 h / 20 °C

2: 94 percent / 2CuO*Cr₂O₃ / quinoline / 180 °C

3: 94 percent / HBr; AcOH / 50 °C

4: 94 percent / Et₃N / CH₂Cl₂

5: 79 percent / NiCl₂(dppe)2

With chromium(III) oxide; hydrogen bromide; titanium tetrachloride; acetic acid; triethylamine; copper(II) oxide; Ni(DPPE)2Cl₂; In quinoline; dichloromethane; 1: Friedel-Crafts reaction;
DOI:10.1055/s-2004-831317