N⁴-(3-chloro-4-fluorophenyl)-7-((7-methyl-7-azaspiro[3.5]non-2-yl)methoxy)quinazolin-4,6-diamine

Base Information

• Chemical Name: N⁴-(3-chloro-4-fluorophenyl)-7-((7-methyl-7-azaspiro[3.5]non-2-yl)methoxy)quinazolin-4,6-diamine
• CAS No.: 1363359-84-5
• Molecular Formula: C₂₄H₂₇ClFN₅O
• Molecular Weight: 455.963

Synonyms:N⁴-(3-chloro-4-fluorophenyl)-7-((7-methyl-7-azaspiro[3.5]non-2-yl)methoxy)quinazolin-4,6-diamine

Chemical Property of N⁴-(3-chloro-4-fluorophenyl)-7-((7-methyl-7-azaspiro[3.5]non-2-yl)methoxy)quinazolin-4,6-diamine

Chemical Property:

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Technology Process of N⁴-(3-chloro-4-fluorophenyl)-7-((7-methyl-7-azaspiro[3.5]non-2-yl)methoxy)quinazolin-4,6-diamine

There total 8 articles about N⁴-(3-chloro-4-fluorophenyl)-7-((7-methyl-7-azaspiro[3.5]non-2-yl)methoxy)quinazolin-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-(4-(3-chloro-4-fluorophenyl))-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)-6-nitroquinazolin-4-amine (1363359-83-4) → N4-(3-chloro-4-fluorophenyl)-7-((7-methyl-7-azaspiro[3.5]non-2-yl)methoxy)quinazolin-4,6-diamine (1363359-84-5)

Guidance literature:

With hydrogen; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine (162012-67-1) → N4-(3-chloro-4-fluorophenyl)-7-((7-methyl-7-azaspiro[3.5]non-2-yl)methoxy)quinazolin-4,6-diamine (1363359-84-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere; Cooling with ice

1.2: 20 °C / Inert atmosphere

2.1: acetic acid; iron / ethanol / 12 h / 20 °C

With iron; sodium hydride; acetic acid; In ethanol; N,N-dimethyl-formamide;

Reference yield:

(7-methyl-7-azaspiro[3.5]nonan-2-yl)methanol (1363360-02-4) → N4-(3-chloro-4-fluorophenyl)-7-((7-methyl-7-azaspiro[3.5]non-2-yl)methoxy)quinazolin-4,6-diamine (1363359-84-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere; Cooling with ice

1.2: 20 °C / Inert atmosphere

2.1: acetic acid; iron / ethanol / 12 h / 20 °C

With iron; sodium hydride; acetic acid; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

(7-methyl-7-azaspiro[3.5]nonan-2-yl)methanol

N-(4-(3-chloro-4-fluorophenyl))-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)-6-nitroquinazolin-4-amine

4-fluoroanthranilic acid

7-fluoro-3H-quinazolin-4-one

Downstream raw materials:

N-(4-((3-chloro-4-fluorophenyl)amino)-7-((7-methyl-7-azaspiro[3 .5]nonan-2-yl)methoxy)quinazolin-6-yl)acrylamide

(E)-N-[4-(3-chloro-4-fluorophenylamino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazolin-6-yl]-2-butenamide

(E)-N-[4-(3-chloro-4-fluorophenylamino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazolin-6-yl]-2-pentenamide hydrochloride

(E)-N-(4-(3-chloro-4-fluoroanilino)-7-((7-methyl-7-azaspirocyclic[3.5]nonan-2-yl)methoxy)quinazolin-6-yl)-4-dimethylamino-2-butenamide

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