Technology Process of Phosphoric acid (5S,6R)-5-benzyloxy-6-benzyloxymethyl-5,6-dihydro-4H-pyran-2-yl ester diphenyl ester
There total 11 articles about Phosphoric acid (5S,6R)-5-benzyloxy-6-benzyloxymethyl-5,6-dihydro-4H-pyran-2-yl ester diphenyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hexamethylsilazane;
In
tetrahydrofuran; toluene;
at -78 ℃;
for 0.5h;
DOI:10.1016/S0040-4020(02)00045-5
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: H2 / 10 percent Pd/C / ethyl acetate; ethanol / 20 °C
2.1: NaOMe / methanol / 0.5 h / 20 °C
3.1: tetra-n-butylammonium iodide; NaH / tetrahydrofuran; dimethylformamide / 0 - 20 °C
3.2: 5.89 g / tetrahydrofuran; dimethylformamide / 0 - 20 °C
4.1: 78 percent / aq. acetic acid; aq. HCl / 48 h / 60 °C
5.1: 78 percent / N-methylmorpholine N-oxide; tetra-n-propylammonium perruthenate; 4 Angstroem molecular sieves / acetonitrile / 4.5 h / 20 °C
6.1: 75 percent / HMPA; potassium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / 0.5 h / -78 °C
With
hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; tetrapropylammonium perruthennate; 4 A molecular sieve; hydrogen; sodium methylate; tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; sodium hydride; acetic acid; 4-methylmorpholine N-oxide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/S0040-4020(02)00045-5
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: BF3*OEt2 / CH2Cl2 / 0 - 20 °C
2.1: H2 / 10 percent Pd/C / ethyl acetate; ethanol / 20 °C
3.1: NaOMe / methanol / 0.5 h / 20 °C
4.1: tetra-n-butylammonium iodide; NaH / tetrahydrofuran; dimethylformamide / 0 - 20 °C
4.2: 5.89 g / tetrahydrofuran; dimethylformamide / 0 - 20 °C
5.1: 78 percent / aq. acetic acid; aq. HCl / 48 h / 60 °C
6.1: 78 percent / N-methylmorpholine N-oxide; tetra-n-propylammonium perruthenate; 4 Angstroem molecular sieves / acetonitrile / 4.5 h / 20 °C
7.1: 75 percent / HMPA; potassium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / 0.5 h / -78 °C
With
hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; tetrapropylammonium perruthennate; 4 A molecular sieve; boron trifluoride diethyl etherate; hydrogen; sodium methylate; tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; sodium hydride; acetic acid; 4-methylmorpholine N-oxide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/S0040-4020(02)00045-5
