1-(4-vinylbenzyl)thymine

Base Information

• Chemical Name: 1-(4-vinylbenzyl)thymine
• CAS No.: 623563-56-4
• Molecular Formula: C₁₄H₁₄N₂O₂
• Molecular Weight: 242.277
• Mol file: 623563-56-4.mol

Synonyms:1-(4-vinylbenzyl)thymine

Chemical Property of 1-(4-vinylbenzyl)thymine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 1-(4-vinylbenzyl)thymine

There total 2 articles about 1-(4-vinylbenzyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

4-Vinylbenzyl chloride (1592-20-7,29296-32-0) + thymin (65-71-4,28806-14-6,691841-57-3) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → 1-(4-vinylbenzyl)thymine (623563-56-4)

Guidance literature:

thymin; 1,1,1,3,3,3-hexamethyl-disilazane; With chloro-trimethyl-silane; for 24h; Heating;

4-Vinylbenzyl chloride; With hydroquinone; sodium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 8h;

With water; for 0.166667h;

DOI:10.1002/jhet.5570400418

Reference yield: 47.0%

4-Vinylbenzyl chloride (1592-20-7,29296-32-0) + thymin (65-71-4,28806-14-6,691841-57-3) → 1-(4-vinylbenzyl)thymine (623563-56-4)

Guidance literature:

thymin; With sodium hydroxide; In ethanol; at 65 ℃; for 0.25h;

4-Vinylbenzyl chloride; In ethanol; at 85 ℃; for 18h;

DOI:10.1021/acs.macromol.7b01782

Reference yield: 75.0%

4-bromopyridine hydrochloride (19524-06-2) + 1-(4-vinylbenzyl)thymine (623563-56-4) → (E)-5-methyl-1-(4-(2-(pyridin-4-yl)vinyl)benzyl)pyrimidine-2,4-(1H,3H)-dione

Guidance literature:

With sodium acetate; palladium diacetate; tris-(o-tolyl)phosphine; In N,N-dimethyl-formamide; at 70 - 140 ℃; Microwave irradiation; Inert atmosphere;

DOI:10.1039/c4pp00185k

upstream raw materials:

4-Vinylbenzyl chloride

thymin

1,1,1,3,3,3-hexamethyl-disilazane

Refernces

• 1、 Saito, Kei,Ingalls, Laura R.,Lee, Jun,Warner, John C.. "Core-bound polymeric micellar system based on photocrosslinking of thymine". . p. 2503 - 2505. Retrieved 2007.
• 2、 Wang, Mu,Choi, Bonnie,Sun, Zhonghe,Wei, Xiaohu,Feng, Anchao,Thang, San H.. "Spindle-like and telophase-like self-assemblies mediated by complementary nucleobase molecular recognition". supporting information. p. 1462 - 1465. Retrieved 2019/02/05.