4-methyl-N-(2-oxo-2-phenylethyl)-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide

Base Information

• Chemical Name: 4-methyl-N-(2-oxo-2-phenylethyl)-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide
• CAS No.: 1427797-94-1
• Molecular Formula: C₂₄H₂₁NO₃S
• Molecular Weight: 403.502
• Mol file: 1427797-94-1.mol

Synonyms:4-methyl-N-(2-oxo-2-phenylethyl)-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide

Chemical Property of 4-methyl-N-(2-oxo-2-phenylethyl)-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-N-(2-oxo-2-phenylethyl)-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide

There total 7 articles about 4-methyl-N-(2-oxo-2-phenylethyl)-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

iodobenzene (591-50-4) + 4-methyl-N-(2-oxo-2-phenylethyl)-N-(prop-2-yn-1-yl)benzenesulfonamide (697287-96-0) → 4-methyl-N-(2-oxo-2-phenylethyl)-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide (1427797-94-1)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; for 6h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.joc.1c00079

Reference yield: 85.0%

α-bromoacetophenone (70-11-1) + 4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide (305837-95-0) → 4-methyl-N-(2-oxo-2-phenylethyl)-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide (1427797-94-1)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

Reference yield:

N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide (18303-04-3) → 4-methyl-N-(2-oxo-2-phenylethyl)-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide (1427797-94-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

1.2: 10 h / 20 °C

2.1: potassium carbonate; tetrabutylammomium bromide / N,N-dimethyl-formamide / 1 h / 0 °C

With tetrabutylammomium bromide; potassium carbonate; In N,N-dimethyl-formamide;

upstream raw materials:

α-bromoacetophenone

4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide

acetophenone

N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide

Downstream raw materials:

C₂₄H₂₃NO₃S