(2R)-2-((1S,5R)-7,7-diphenyl-6,8-diazabicyclo[3.2.1]oct-8-yl)-2-phenylethanol

Base Information

Chemical Name:(2R)-2-((1S,5R)-7,7-diphenyl-6,8-diazabicyclo[3.2.1]oct-8-yl)-2-phenylethanol
CAS No.:181872-31-1
Molecular Formula:C₂₆H₂₈N₂O
Molecular Weight:384.521
Hs Code.:

Synonyms:(2R)-2-((1S,5R)-7,7-diphenyl-6,8-diazabicyclo[3.2.1]oct-8-yl)-2-phenylethanol

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Chemical Property of (2R)-2-((1S,5R)-7,7-diphenyl-6,8-diazabicyclo[3.2.1]oct-8-yl)-2-phenylethanol

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Technology Process of (2R)-2-((1S,5R)-7,7-diphenyl-6,8-diazabicyclo[3.2.1]oct-8-yl)-2-phenylethanol

There total 1 articles about (2R)-2-((1S,5R)-7,7-diphenyl-6,8-diazabicyclo[3.2.1]oct-8-yl)-2-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 88056-92-2
(-)-2-cyano-6-phenyloxazolopiperidine

: 591-51-5
phenyllithium

: 181872-31-1
(2R)-2-((1S,5R)-7,7-diphenyl-6,8-diazabicyclo[3.2.1]oct-8-yl)-2-phenylethanol

Guidance literature:: With lithium bromide; In diethyl ether; at -20 - 20 ℃; for 1.5h;
DOI:10.1021/jo960910s

Reference yield: 96.0%

: 181872-31-1
(2R)-2-((1S,5R)-7,7-diphenyl-6,8-diazabicyclo[3.2.1]oct-8-yl)-2-phenylethanol

: 181872-32-2
(R)-2-[(S)-2-(Amino-diphenyl-methyl)-piperidin-1-yl]-2-phenyl-ethanol

Guidance literature:: With sodium tetrahydroborate; In methanol; for 2.5h; Ambient temperature;
DOI:10.1021/jo960910s

Reference yield:

: 181872-31-1
(2R)-2-((1S,5R)-7,7-diphenyl-6,8-diazabicyclo[3.2.1]oct-8-yl)-2-phenylethanol

: C-((S)-C,C-Diphenyl-C-piperidin-2-yl)-methylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / NaBH₄ / methanol / 2.5 h / Ambient temperature

2: 79 percent / Et₃N / CH₂Cl₂ / 4 h / 20 °C

3: 1) H₂, conc. HCl, 2) aq. HCl / 1) Pd/C / 1) MeOH, 1 h, 2) MeOH, reflux, 12 h

With hydrogenchloride; sodium tetrahydroborate; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jo960910s